慢性精神分裂症患者脑谷胱甘肽水平与发病年龄的关系。
Brain glutathione levels and age at onset of illness in chronic schizophrenia.
机构信息
VISN22 Mental Illness Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
出版信息
Acta Neuropsychiatr. 2019 Dec;31(6):343-347. doi: 10.1017/neu.2019.29. Epub 2019 Aug 27.
OBJECTIVE
Oxidative stress is implicated in the aetiology of schizophrenia, and the antioxidant defence system (AODS) may be protective in this illness. We examined the major antioxidant glutathione (GSH) in prefrontal brain and its correlates with clinical and demographic variables in schizophrenia.
METHODS
GSH levels were measured in the dorsolateral prefrontal region of 28 patients with chronic schizophrenia using a magnetic resonance spectroscopy sequence specifically adapted for GSH. We examined correlations of GSH levels with age, age at onset of illness, duration of illness, and clinical symptoms.
RESULTS
We found a negative correlation between GSH levels and age at onset (r = -0.46, p = 0.015), and a trend-level positive relationship between GSH and duration of illness (r = 0.34, p = 0.076).
CONCLUSION
Our findings are consistent with a possible compensatory upregulation of the AODS with longer duration of illness and suggest that the AODS may play a role in schizophrenia.
目的
氧化应激与精神分裂症的病因有关，抗氧化防御系统（AODS）可能对此病具有保护作用。我们研究了精神分裂症患者前额叶大脑中的主要抗氧化剂谷胱甘肽（GSH）及其与临床和人口统计学变量的相关性。
方法
使用专门适用于 GSH 的磁共振波谱序列，我们测量了 28 名慢性精神分裂症患者的背外侧前额叶区域中的 GSH 水平。我们检查了 GSH 水平与年龄、发病年龄、疾病持续时间和临床症状之间的相关性。
结果
我们发现 GSH 水平与发病年龄呈负相关（r = -0.46，p = 0.015），而 GSH 与疾病持续时间呈正相关（r = 0.34，p = 0.076）。
结论
我们的发现与 AODS 随着疾病持续时间的延长而可能发生代偿性上调一致，并表明 AODS 可能在精神分裂症中起作用。
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