通过细胞成像和放射疗法增强 CAR T 细胞疗法。
Enhancing CAR T-cell therapy through cellular imaging and radiotherapy.
机构信息
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Lancet Oncol. 2019 Aug;20(8):e443-e451. doi: 10.1016/S1470-2045(19)30461-9. Epub 2019 Jul 29.
Chimeric antigen receptor (CAR) T-cell therapy is one of the most remarkable advances in cancer therapy in the last several decades. More than 300 adoptive T-cell therapy trials are ongoing, which is a testament to the early success and hope engendered by this line of investigation. Despite the enthusiasm, application of CAR T-cell therapy to solid tumours has had little success, although positive outcomes are increasingly being reported for these diseases. In this Series paper, we discuss the short-term strategies to improve CAR T-cell therapy responses, particularly for solid tumours, by combining CAR T-cell therapy with radiotherapy through the use of careful monitoring and non-invasive imaging. Through the use of imaging, we can gain greater mechanistic insights into the cascade of events that must unfold to enable tumour eradication by CAR T-cell therapy.
嵌合抗原受体 (CAR) T 细胞疗法是过去几十年癌症治疗中最显著的进展之一。目前正在进行 300 多项过继性 T 细胞疗法试验，这证明了这条研究路线的早期成功和带来的希望。尽管如此，CAR T 细胞疗法在实体瘤中的应用收效甚微，尽管这些疾病的阳性结果越来越多。在本系列论文中，我们讨论了通过使用仔细的监测和非侵入性成像，将 CAR T 细胞疗法与放射疗法相结合，从而改善 CAR T 细胞疗法反应的短期策略，特别是针对实体瘤。通过使用成像，我们可以更深入地了解 CAR T 细胞疗法消除肿瘤所必须展开的一系列事件的机制。
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