Corda M, Dessì M R, Floris G
Istituto di Chimica Biologica Università di Cagliari, Italy.
Physiol Chem Phys Med NMR. 1988;20(1):37-42.
The enzymatic deamination of Se-lanthionamine (Se-L), Se-homolanthionamine (Se-HL) and Se-homocystamine (Se-HC) catalyzed by pig kidney diamine oxidase (PKAO) has been studied to collect information about the possible metabolic reactions of selenocompounds in comparison with the sulfur ones. The results indicate that: Se-L, Se-HL and Se-HC are substrates for PKAO. The first product of Se-L, Se-HL and Se-HC oxidative deamination, in analogy with other thio and seleno diamines, may be the cyclized aminoaldehyde. The final product of Se-L, Se-HL and Se-HC degradation are ammonia, elemental selenium and C2 or C3 compounds.
为了收集有关硒化合物与硫化合物相比可能的代谢反应的信息，研究了猪肾二胺氧化酶（PKAO）催化的硒代羊毛硫氨酸（Se-L）、硒代高羊毛硫氨酸（Se-HL）和硒代高胱胺（Se-HC）的酶促脱氨反应。结果表明：Se-L、Se-HL和Se-HC是PKAO的底物。与其他硫代和硒代二胺类似，Se-L、Se-HL和Se-HC氧化脱氨的首个产物可能是环化氨基醛。Se-L、Se-HL和Se-HC降解的最终产物是氨、元素硒和C2或C3化合物。
