Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelburg University, Mannheim, Germany.
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelburg University, Mannheim, Germany.
Biol Psychiatry. 2019 Dec 15;86(12):930-938. doi: 10.1016/j.biopsych.2019.06.008. Epub 2019 Jun 19.
Heightened amygdala response to threatening cues has been repeatedly observed in borderline personality disorder (BPD). A previous report linked hyperactivation to deficient amygdala habituation to repeated stimuli, but the biological underpinnings are incompletely understood.
We examined a sample of 120 patients with BPD and 115 healthy control subjects with a well-established functional magnetic resonance imaging emotional face processing task to replicate the previously reported amygdala habituation deficit in BPD and probed this neural phenotype for associations with symptom severity and early social risk exposure.
Our results confirm a significant reduction in amygdala habituation to repeated negative stimuli in BPD (p = .015, peak-level familywise error [FWE] corrected for region of interest). Post hoc comparison and regression analysis did not suggest a role for BPD clinical state (p > .56) or symptom severity (p > .45) for this phenotype. Furthermore, deficient amygdala habituation was significantly related to increased exposure to adverse childhood experiences (p = .013, region of interest corrected).
Our data replicate a prior report on deficient amygdala habituation in BPD and link this neural phenotype to early adversity, a well-established social environmental risk factor for emotion dysregulation and psychiatric illness.
边缘型人格障碍（BPD）患者的杏仁核对威胁性线索的反应增强已被反复观察到。之前的一项研究报告将过度活跃与杏仁核对重复刺激的习惯化缺陷联系起来，但生物学基础尚不完全清楚。
我们使用一种经过充分验证的功能性磁共振成像情绪面孔处理任务，对 120 名 BPD 患者和 115 名健康对照者进行了检查，以复制 BPD 中先前报道的杏仁核习惯化缺陷，并探讨这种神经表型与症状严重程度和早期社会风险暴露的关联。
我们的结果证实了 BPD 患者对重复出现的负性刺激的杏仁核习惯化明显减少（p=0.015，基于感兴趣区的峰水平全脑错误校正）。事后比较和回归分析表明，这种表型与 BPD 的临床状态（p>.56）或症状严重程度（p>.45）无关。此外，杏仁核习惯化不足与暴露于更多的不良童年经历显著相关（p=0.013，基于感兴趣区的校正）。
我们的数据复制了 BPD 中杏仁核习惯化不足的先前报告，并将这种神经表型与早期逆境联系起来，早期逆境是情绪失调和精神疾病的一个公认的社会环境风险因素。
