Ma Ji-Hong, Peng Yong-Jun, Sun Jian-Hua, Zhu Bing-Mei
Department of Acupuncture-moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine and Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China.
Department of Acupuncture-moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine and Jiangsu Provincial Hospital of Traditional Chinese Me-dicine, Nanjing 210029, China.
Zhen Ci Yan Jiu. 2019 Jul 25;44(7):538-42. doi: 10.13702/j.1000-0607.180786.
At present, intestinal flora has attracted more and more attention from scholars in China and foreign countries, and its association with ischemic stroke (IS) has gradually become a new research hotspot in the field of stroke. Studies also showed that intestinal flora may be a risk factor which directly or indirectly affects the occurrence and development of IS through bacterial metabolites and immune activities. In the present paper, we review the positive effect of acupuncture and moxibustion in alleviating the symptoms of limb locomotor, speech, swallowing dysfunction, cognition, etc. to improve the IS patients' daily life ability and in strengthening the cellular immune function of the body. In addition, acupuncture and moxibustion have a positive effect in regulating intestinal flora and immune inflammation. Hence, in the present paper, we discuss their relationship and the possibility of application of acupuncture and moxibustion therapies to the treatment of IS according to the theory of "intestinal flora-immune response". It is thus reasonable to speculate that acupuncture and moxibustion can be used to promote the recovery of brain tissue injury and neurological function after stroke via correcting intestinal flora disturbance and reducing immune inflammatory response. In-depth exploration of the role of "intestinal flora-immune response" in the treatment of IS and the specific regulatory function of acupuncture and moxibustion will provide new ideas and research approaches to reveal their mechanisms in the treatment of stroke from a new perspective.
目前，肠道菌群已越来越受到国内外学者的关注，其与缺血性脑卒中（IS）的关联逐渐成为脑卒中领域新的研究热点。研究还表明，肠道菌群可能是通过细菌代谢产物和免疫活动直接或间接影响IS发生发展的一个危险因素。在本文中，我们综述了针灸在缓解肢体运动、言语、吞咽功能障碍、认知等症状以提高IS患者日常生活能力以及增强机体细胞免疫功能方面的积极作用。此外，针灸在调节肠道菌群和免疫炎症方面也有积极作用。因此，在本文中，我们根据“肠道菌群-免疫反应”理论探讨它们之间的关系以及针灸疗法应用于IS治疗的可能性。据此合理推测，针灸可通过纠正肠道菌群紊乱和减轻免疫炎症反应来促进脑卒中后脑组织损伤和神经功能的恢复。深入探究“肠道菌群-免疫反应”在IS治疗中的作用以及针灸的具体调节功能，将为从新的角度揭示其治疗脑卒中的机制提供新的思路和研究方法。
