惊恐障碍患者自杀风险因素的系统评价和荟萃分析。
Risk factors for suicidality in patients with panic disorder: A systematic review and meta-analysis.
机构信息
Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Graduation Program in Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Graduation Program in Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
出版信息
Neurosci Biobehav Rev. 2019 Oct;105:34-38. doi: 10.1016/j.neubiorev.2019.07.022. Epub 2019 Jul 31.
BACKGROUND
Subjects with panic disorder are nearly 4 times as likely to attempt suicide as compared to subjects without this condition.
METHODS
We searched the literature from Jan 1, 1960 to May, 4, 2019. Articles that reported a dichotomous sample of patients with panic disorder with and without suicidal behavior were included.
OUTCOMES
Twelve studies with 1958 participants were included. Comorbid depression (k = 3, ES = 4.47 [2.63; 7.60]), depressive symptoms (k = 2, ES = 1.98 [1.26; 3.11]), older age (k = 3, ES = 1.66 [1.32; 2.10]), younger age of panic disorder onset (k = 2, ES = 0.65 [0.45; 0.94]), and history of alcohol dependence (k = 2, ES = 8.70 [1.20; 63.04]) were associated with suicide attempt in panic disorder. Depressive symptoms (k = 2, ES = 2.29 (1.60; 3.37]), anxiety symptoms (k = 2, ES = 1.90 [1.33; 2.69]), longer illness duration (k = 2, ES = 3.31 [1.90; 5.74]), comorbid depressive disorder (k = 4, ES = 3.88 [2.03; 7.41]), agoraphobia (k = 2, ES = 4.60 [1.47; 14.42]) and younger age of onset (k = 2, ES = 0.60 [0.38; 0.96]) were associated with suicidal ideation in panic disorder.
INTERPRETATION
Our findings provide a framework for the development of suicide prevention strategies in this population.
背景
与没有这种情况的患者相比，患有惊恐障碍的患者自杀的可能性几乎高出四倍。
方法
我们从 1960 年 1 月 1 日至 2019 年 5 月 4 日搜索了文献。纳入报告惊恐障碍患者有和无自杀行为的二分样本的文章。
结果
共纳入 12 项研究，共 1958 名参与者。合并抑郁症（k=3，ES=4.47[2.63；7.60]）、抑郁症状（k=2，ES=1.98[1.26；3.11]）、年龄较大（k=3，ES=1.66[1.32；2.10]）、惊恐障碍发病年龄较小（k=2，ES=0.65[0.45；0.94]）和酒精依赖史（k=2，ES=8.70[1.20；63.04]）与惊恐障碍患者自杀企图有关。抑郁症状（k=2，ES=2.29[1.60；3.37]）、焦虑症状（k=2，ES=1.90[1.33；2.69]）、病程较长（k=2，ES=3.31[1.90；5.74]）、合并抑郁障碍（k=4，ES=3.88[2.03；7.41]）、广场恐怖症（k=2，ES=4.60[1.47；14.42]）和发病年龄较小（k=2，ES=0.60[0.38；0.96]）与惊恐障碍患者的自杀意念有关。
结论
我们的研究结果为该人群制定自杀预防策略提供了框架。
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