Comprehensive Pneumology Center and Institute for Lung Biology and Disease, University Hospital, Ludwig-Maximilians University of Munich and Helmholtz Center Munich, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Bavaria, Germany.
Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Biomedical Sciences Research Center, 1 Asklepiou Str., University Campus, 26504 Rio, Achaia, Greece.
Cells. 2019 Aug 2;8(8):815. doi: 10.3390/cells8080815.
The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.
糖蛋白骨桥蛋白（OPN）在健康和疾病中具有多种功能。为此，OPN 在伤口愈合、骨骼动态平衡和细胞外基质（ECM）功能中发挥有益作用。相反，OPN 在疾病期间对人体可能是有害的。事实上，OPN 是肿瘤相关炎症的主要介质，并促进转移。本文旨在强调 OPN 在恶性过程中的重要性，以肺和胸膜肿瘤为例。
