Ferhi Fehmi, Dardour Leïla, Tej Amel, Kebaili Raoudha, M'aaref Sarra, Jazia Khaled Ben
Department of Anesthesiology-Intensive Care, University Hospital Farhat Hached, Sousse, Tunisia.
Department of Medical Genetics, Faculty of Medicine of Sousse, Sousse, Tunisia.
Saudi J Ophthalmol. 2019 Apr-Jun;33(2):183-187. doi: 10.1016/j.sjopt.2018.10.002. Epub 2018 Oct 19.
Malignant hyperthermia (MH) is a rare pharmacogenic disorder of skeletal muscle calcium regulation, resulting from general anesthesia that can be fatal. Most cases are caused by administration of volatile anesthetics or depolarizing muscle relaxants. It has been generally reported that both of sevoflurane and succinylcholine can induce the delayed onset of MH. Here, we report a case of malignant hyperthermia in a four-year-old girl during anesthesia induction for unilateral congenital ptosis surgery, two minutes after sevoflurane and succinylcholine administration. The crisis was atypical but early recognized and managed by administration of dantrolene with symptomatic treatment.
恶性高热（MH）是一种罕见的骨骼肌钙调节药物性疾病，由可致命的全身麻醉引起。大多数病例是由使用挥发性麻醉剂或去极化肌肉松弛剂所致。普遍报道称，七氟烷和琥珀酰胆碱均可诱发延迟性恶性高热发作。在此，我们报告一例4岁女童在单侧先天性上睑下垂手术麻醉诱导期间发生恶性高热的病例，该患儿在给予七氟烷和琥珀酰胆碱2分钟后发病。此次危象不典型，但通过给予丹曲林并进行对症治疗得以早期识别和处理。
