原发性青光眼的 HLA-DPA1 基因多态性。
HLA-DPA1 gene polymorphism in primary glaucoma.
机构信息
Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China.
出版信息
Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):24-30. doi: 10.26355/eurrev_201908_18623.
OBJECTIVE
To explore the association between human leukocyte antigen (HLA)-DPA1 gene polymorphism and primary glaucoma.
PATIENTS AND METHODS
Six single nucleotide polymorphisms (SNPs) were genotyped in 51 patients and 51 healthy controls through Polymerase Chain Reaction (PCR). The possible association between HLA-DPA1 gene mutation and primary glaucoma was detected using the t-test and the Chi-square test.
RESULTS
Rs1676486 genotype had a significant genetic correlation. Rs3753841 and rs12138977 genotypes had a higher minor-allele frequency in control group. The CT + CC genotype frequency of rs12138977 showed a significant genetic correlation in both case group and control group. Moreover, the rs12138977 polymorphism and corneal thickness had little influence on the occurrence of primary angle-closure glaucoma (PACG). Also, the main risk factors for PACG were intraocular hypertension and short axial length.
CONCLUSIONS
The HLA-DPA1 gene polymorphism may be related to the severity of PACG.
目的
探讨人类白细胞抗原（HLA）-DPA1 基因多态性与原发性青光眼的关系。
方法
采用聚合酶链反应（PCR）技术对 51 例原发性青光眼患者和 51 例健康对照者的 6 个单核苷酸多态性（SNP）进行基因分型。采用 t 检验和卡方检验检测 HLA-DPA1 基因突变与原发性青光眼的可能关联。
结果
rs1676486 基因型存在显著的遗传相关性。rs3753841 和 rs12138977 基因型在对照组中的次要等位基因频率较高。rs12138977 的 CT+CC 基因型频率在病例组和对照组均表现出显著的遗传相关性。此外，rs12138977 多态性和角膜厚度对原发性闭角型青光眼（PACG）的发生影响较小。PACG 的主要危险因素是眼内压升高和短轴长度。
结论
HLA-DPA1 基因多态性可能与 PACG 的严重程度有关。
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