Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Pediatrics, Faculty of Medicine, University of Colombo, Sri Lanka.
J Pediatr. 2019 Nov;214:141-150. doi: 10.1016/j.jpeds.2019.06.059. Epub 2019 Aug 6.
To systematically review the literature on health-related quality of life (HRQoL) in children with functional constipation and to identify disease-related factors associated with HRQoL.
The Pubmed, Embase, and PsycINFO database were searched. Studies were included if they prospectively assessed HRQoL in children with functional constipation according to the Rome criteria. Articles were excluded if patients had organic causes of constipation and if HRQoL was only assessed after successful therapeutic interventions. A meta-analysis was performed calculating sample size-weighted pooled mean and SD of HRQoL scores. The quality of the studies was also assessed.
A total of 20 of 2658 studies were included, providing HRQoL data for 2344 children. Quality of evidence was considered to be poor in 9 of the 20 studies (45%); 13 of the 20 studies reported sufficient data to be included in the meta-analysis. Pooled total HRQoL scores of children with functional constipation were found to be lower compared with healthy reference samples (65.6 vs 86.1; P < .01). Similar HRQoL scores were found according to self-report and parent proxy report. Hospital-based studies reported lower HRQoL scores as compared with community-based studies. Two studies reported on HRQoL scores of children with and without fecal incontinence, but no significant difference was found.
HRQoL is compromised in children with functional constipation.
系统回顾功能性便秘儿童健康相关生活质量（HRQoL）的文献，并确定与 HRQoL 相关的疾病相关因素。
检索了 Pubmed、Embase 和 PsycINFO 数据库。如果前瞻性评估了符合罗马标准的功能性便秘儿童的 HRQoL，则纳入研究。如果患者有便秘的器质性原因，或者仅在成功的治疗干预后评估 HRQoL，则排除这些文章。对研究进行了 meta 分析，计算了 HRQoL 评分的样本大小加权平均和 SD。还评估了研究的质量。
从 2658 篇研究中筛选出 20 篇，为 2344 名儿童提供了 HRQoL 数据。20 项研究中有 9 项（45%）的证据质量被认为较差；20 项研究中有 13 项报告了足够的数据纳入 meta 分析。与健康参考样本相比，功能性便秘儿童的总体 HRQoL 评分较低（65.6 比 86.1；P <.01）。根据自我报告和家长代理报告，发现 HRQoL 评分相似。与基于社区的研究相比，基于医院的研究报告的 HRQoL 评分较低。有两项研究报告了有和没有粪便失禁的儿童的 HRQoL 评分，但没有发现显著差异。
功能性便秘儿童的 HRQoL 受损。
