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点击化学在药物发现中的可靠性:个人述评。

Reliability of Click Chemistry on Drug Discovery: A Personal Account.

机构信息

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.

出版信息

Chem Rec. 2020 Apr;20(4):253-272. doi: 10.1002/tcr.201900027. Epub 2019 Aug 16.

Abstract

The unprecedented efficiency, reliability and adaptability in drug discovery, with the growing number of applications and impact, have made Click Chemistry fascinating to the scientific community. The specificity, biocompatibility along with other principles of click chemistry offers a reliable platform for the synthesis of drug-like molecules that can expedite the drug discovery process. This account summarizes such successes of versatile click reactions from our research group towards the development of functional molecules.

摘要

点击化学在药物发现中具有前所未有的效率、可靠性和适应性,随着应用和影响的不断增加,引起了科学界的极大关注。点击化学的特异性、生物相容性和其他原则为类似药物分子的合成提供了可靠的平台,从而可以加速药物发现过程。本综述总结了我们研究小组在利用多功能点击反应开发功能分子方面的一些成功案例。

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