Raison J, London G, Safar M
Centre de diagnostic, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1988 Jun;81 Spec No:65-9.
Forearm hemodynamics using pulsed Doppler flowmetry were studied in 83 men: 15 non-obese and 8 obese normotensive subjects; and 30 non-obese and 30 obese hypertensive patients. Mean ages were similar in the four subgroups. The blood pressure of normotensives and hypertensives was identical in obese and non-obese subjects. Blood flow expressed in ml/mn was significantly higher in obese subjects whether normotensive or hypertensive. However, when blood flow was expressed per unit liter of forearm volume, it was similar in the four subgroups. Forearm vascular resistance, whether expressed as absolute of normalized values, was significantly higher (p less than 0.001) in non-obese hypertensives. When obese and non-obese hypertensives were compared, the former were characterized by higher values of blood velocity and blood flow, and lower values of vascular resistance, whether absolute or normalized values were used. The present study shows that: (i) forearm vascular resistance in hypertensives is increased exclusively in non-obese subjects, and (ii) obese hypertensives, when compared with non-obese hypertensives, are characterized by a hyperkinetic forearm circulation.
我们使用脉冲多普勒血流仪对83名男性的前臂血流动力学进行了研究,其中包括15名非肥胖和8名肥胖的血压正常受试者,以及30名非肥胖和30名肥胖的高血压患者。四个亚组的平均年龄相似。肥胖和非肥胖受试者中,血压正常者和高血压患者的血压相同。无论血压正常还是高血压,肥胖受试者以毫升/分钟表示的血流量均显著更高。然而,当按前臂体积每升表示血流量时,四个亚组的血流量相似。非肥胖高血压患者的前臂血管阻力,无论以绝对值还是标准化值表示,均显著更高(p<0.001)。当比较肥胖和非肥胖高血压患者时,无论使用绝对值还是标准化值,前者的特点是血流速度和血流量较高,血管阻力较低。本研究表明:(i)高血压患者的前臂血管阻力仅在非肥胖受试者中增加;(ii)与非肥胖高血压患者相比,肥胖高血压患者的前臂循环具有高动力性。