Banse H E, Getachew F, Levy M, Smits J
Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z1, Canada.
Domest Anim Endocrinol. 2020 Jul;72:106375. doi: 10.1016/j.domaniend.2019.07.003. Epub 2019 Jul 19.
Hair cortisol has been demonstrated to reflect hypothalamic-pituitary-adrenal axis activity (including Cushing's disease and stress) in several species. We hypothesized that hair cortisol concentrations are increased in horses with pituitary pars intermedia dysfunction (PPID) compared with healthy adult horses and that this difference is magnified in the fall, when circulating adrenocorticotropin (ACTH) is generally the highest. Cortisol from hair collected using clippers with a #40 blade from the neck was compared between PPID horses and control horses over several months in the fall (August-December) and 1 mo in spring (May). Cortisol from hair at several sampling sites (neck, jugular furrow, sternum, and submandibular) were compared between PPID (n = 6) and control (n = 8) horses in May. Relationships between hair cortisol and ACTH were assessed in the fall. Hair cortisol when measured by weight was higher in PPID vs control horses in October and November (P ≤ 0.01) but not December (P = 0.15), May (P > 0.7), or August-September (P = 0.18). When normalized for hair length, hair cortisol was higher in PPID vs control horses in November (P = 0.0006), but not October or December (P ≥ 0.06). Hair cortisol concentrations did not differ between PPID and control horses from any collection site in May (P > 0.7). There were no consistent relationships between ACTH and hair cortisol concentrations in October, November, or December (P ≥ 0.05). These findings suggest that PPID horses have increased hair cortisol accumulation in the fall compared with control horses. Additional work is needed to clarify whether assessing cortisol per weight or per hair length is most relevant in the horse.
毛发皮质醇已被证明能反映多种物种的下丘脑 - 垂体 - 肾上腺轴活动（包括库欣病和应激）。我们推测，与健康成年马相比，患有垂体中间部功能障碍（PPID）的马的毛发皮质醇浓度会升高，并且这种差异在秋季会放大，因为此时循环促肾上腺皮质激素（ACTH）通常是最高的。在秋季（8月至12月）的几个月以及春季的1个月（5月），比较了使用40号刀片的理发器从颈部采集的PPID马和对照马毛发中的皮质醇。5月时，比较了PPID（n = 6）和对照（n = 8）马在几个采样部位（颈部、颈静脉沟、胸骨和下颌下）毛发中的皮质醇。秋季评估了毛发皮质醇与ACTH之间的关系。按重量测量时，10月和11月PPID马的毛发皮质醇高于对照马（P≤0.01），但12月（P = 0.15）、5月（P>0.7）或8 - 9月（P = 0.18）并非如此。按毛发长度进行标准化后，11月PPID马的毛发皮质醇高于对照马（P = 0.0006），但10月或12月并非如此（P≥0.06）。5月时，PPID马和对照马在任何采集部位的毛发皮质醇浓度均无差异（P>0.7）。10月、11月或12月，ACTH与毛发皮质醇浓度之间没有一致的关系（P≥0.05）。这些发现表明，与对照马相比，秋季PPID马的毛发皮质醇积累增加。需要进一步的研究来阐明在马中评估每重量或每毛发长度的皮质醇哪种最为相关。
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