贝尔麻痹患者血清缺血修饰白蛋白水平的评估。
Evaluation of serum ischaemia-modified albumin levels in patients with Bell's palsy.
作者信息
Göker A E, Alagöz M H, Güntaş G, Baskadem Yilmazer A, Berkiten G, Tutar B, Ekincioglu M E, Akgun M F, Uyar Y, Ozdemir E
机构信息
Department of Otorhinolaryngology - Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Department of Biochemistry, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey.
出版信息
J Laryngol Otol. 2019 Sep;133(9):810-813. doi: 10.1017/S0022215119001683. Epub 2019 Aug 22.
OBJECTIVE
This prospective study aimed to evaluate the relationship between serum ischaemia-modified albumin levels and Bell's palsy severity.
METHODS
The study included 30 patients diagnosed with Bell's palsy and 30 healthy individuals. The patients were separated into three disease severity groups (grades 2, 3 and 4) according to House-Brackmann classification. Blood samples were collected from all participants and the results compared between groups.
RESULTS
Significant differences in serum ischaemia-modified albumin were found between the study and control groups (p < 0.001); values were significantly higher in the study group than in the control group.
CONCLUSION
The significantly higher levels of serum ischaemia-modified albumin in the study group suggest that Bell's palsy pathogenesis is associated with oxidative stress.
目的
本前瞻性研究旨在评估血清缺血修饰白蛋白水平与贝尔面瘫严重程度之间的关系。
方法
该研究纳入了30例被诊断为贝尔面瘫的患者和30名健康个体。根据House-Brackmann分类法，将患者分为三个疾病严重程度组（2级、3级和4级）。采集所有参与者的血样，并对各组结果进行比较。
结果
研究组和对照组之间血清缺血修饰白蛋白存在显著差异（p < 0.001）；研究组的值显著高于对照组。
结论
研究组中血清缺血修饰白蛋白水平显著升高表明贝尔面瘫的发病机制与氧化应激有关。
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