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The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns.

作者信息

Hein Daniel, Dreisig Karin, Metzler Markus, Izraeli Shai, Schmiegelow Kjeld, Borkhardt Arndt, Fischer Ute

机构信息

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Department of Pediatrics and Adolescent Medicine, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and University of Copenhagen, Copenhagen, Denmark.

出版信息

Blood. 2019 Oct 17;134(16):1355-1358. doi: 10.1182/blood.2019002215.

Abstract
摘要

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本文引用的文献

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A causal mechanism for childhood acute lymphoblastic leukaemia.
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Five percent of healthy newborns have an fusion as revealed by DNA-based GIPFEL screening.
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