用于人脑肿瘤成像的O-(2-[F]氟乙基)-L-酪氨酸([F]FET)的简便全自动化放射性合成及质量控制
Facile fully automated radiosynthesis and quality control of O-(2-[F]fluoroethyl)-l-tyrosine ([F]FET) for human brain tumor imaging.
作者信息
Wang Min, Glick-Wilson Barbara E, Zheng Qi-Huang
机构信息
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN, 46202, USA.
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN, 46202, USA.
出版信息
Appl Radiat Isot. 2019 Dec;154:108852. doi: 10.1016/j.apradiso.2019.108852. Epub 2019 Aug 12.
O-(2-[F]Fluoroethyl)--tyrosine ([F]FET) has become one of the most successful amino acid tracers for human brain tumor imaging with positron emission tomography (PET). Facile fully automated radiosynthesis and quality control (QC) of [F]FET using our home-built automated multi-purpose F-radiosynthesis module are described. [F]FET was produced in 75-80 min overall synthesis time with 20-25% radiochemical yield decay corrected to end of bombardment (EOB), based on H[F]F. The radiochemical and enantiomeric purities were >99%, and the molar activity (A) was 189-411 GBq/μmol at EOB. The [F]FET dose meets all QC criteria for clinical use, and is suitable for clinical PET study of brain tumor.
O-(2-[¹⁸F]氟乙基)-L-酪氨酸([¹⁸F]FET)已成为用于正电子发射断层扫描(PET)人脑肿瘤成像最成功的氨基酸示踪剂之一。本文描述了使用我们自制的自动化多功能¹⁸F放射性合成模块对[¹⁸F]FET进行简便的全自动放射性合成及质量控制(QC)。基于H[¹⁸F]，[¹⁸F]FET的总合成时间为75 - 80分钟，放射性化学产率经衰减校正至轰击结束(EOB)时为20 - 25%。放射性化学纯度和对映体纯度均>99%，EOB时的摩尔活度(A)为189 - 411 GBq/μmol。[¹⁸F]FET剂量符合临床使用的所有QC标准，适用于脑肿瘤的临床PET研究。
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