微小舞者：EFCAB9 通过 CatSper 触发精子超激活。

Tiny Dancer: EFCAB9 Triggers Sperm Hyperactivation via CatSper.

机构信息

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

出版信息

Trends Biochem Sci. 2019 Oct;44(10):823-826. doi: 10.1016/j.tibs.2019.08.001. Epub 2019 Aug 22.

DOI:10.1016/j.tibs.2019.08.001

Abstract

The Ca-conducting ion channel, CatSper, is expressed exclusively on the sperm flagellum and regulates sperm motility. A new study (Hwang et al., Cell, 2019) reveals that the pH-sensing and Ca-binding protein, EFCAB9, is a subunit of the CatSper channel and has a key role in triggering mammalian sperm to change their swimming at fertilization.

摘要

钙离子通道 CatSper 仅在精子鞭毛上表达，调节精子运动。一项新的研究（Hwang 等人，《细胞》，2019）揭示了 pH 感应和 Ca 结合蛋白 EFCAB9 是 CatSper 通道的一个亚基，在触发哺乳动物精子在受精时改变游动方式方面起着关键作用。