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在早期激素受体阳性乳腺癌的老年患者中,放疗和前哨淋巴结活检的遗漏越来越多。

Increasing omission of radiation therapy and sentinel node biopsy in elderly patients with early stage, hormone-positive breast cancer.

机构信息

Department of Surgery, University of Colorado, Aurora, Colorado.

出版信息

Breast J. 2020 Feb;26(2):133-138. doi: 10.1111/tbj.13483. Epub 2019 Aug 25.


DOI:10.1111/tbj.13483
PMID:31448508
Abstract

Prospective evidence demonstrates that there is limited benefit of axillary staging with sentinel lymph node biopsy (SLNB) or radiation therapy (RT) in patients over age 70 with clinical stage I, hormone-positive breast cancer. The clinical impact of this literature is unknown. Our hypothesis is that omission of SLNB and RT has increased over time in these patients, and patient and tumor characteristics can predict when omission strategies are used. A single-center tumor registry was queried for all patients over age 70 with ER+, Her2/neu-negative, clinical T1N0 invasive breast cancer from 2009 to 2017, who underwent breast conservation (n = 141). Date of treatment, age, tumor characteristics, use of SLNB, and use of RT were evaluated. The trend of treatment strategy over time was evaluated. Multivariable analysis was performed on the subgroup of patients after publication of the long-term follow-up CALGB 9343 data . Patients undergoing treatment with omission of RT and SLNB increased over the study period (P = .0006). Patients who did not receive RT were older (78.76 years ± 5.48 vs 73.37 ± 3.63, P < .01). There was no difference between tumor grade and size between uses of RT. Of patients who received SLNB (n = 84), only 3 (3.5%) had a positive LN. On multivariable analysis of patients who were treated after publication of the CALGB 9343 data (2014-2017), only age was predictive of being treated with RT (OR, 0.77; 95% CI, 0.67-0.88). Omission of both RT and SLNB are increasing in clinical practice in appropriately selected patients. The likelihood that patients are offered omission of these interventions increases with age. Low nodal positivity rates suggest that this strategy may be underutilized. Tumor grade and size were not predictive of omission of RT in this group of low-risk patients. Long-term data are needed as these approaches are increasingly adopted.

摘要

前瞻性证据表明,对于临床 I 期、激素受体阳性的 70 岁以上乳腺癌患者,腋窝分期加前哨淋巴结活检(SLNB)或放疗(RT)的获益有限。该文献的临床影响尚不清楚。我们的假设是,随着时间的推移,这些患者中 SLNB 和 RT 的遗漏率增加,患者和肿瘤特征可以预测何时采用遗漏策略。对 2009 年至 2017 年间在我院接受保乳治疗的所有年龄在 70 岁以上、ER+、HER2/neu 阴性、临床 T1N0 浸润性乳腺癌的患者进行了单中心肿瘤登记,共 141 例。评估治疗日期、年龄、肿瘤特征、SLNB 应用和 RT 应用。评估了随时间推移的治疗策略趋势。对长期随访 CALGB 9343 数据公布后的亚组患者进行了多变量分析。在研究期间,接受遗漏 RT 和 SLNB 治疗的患者逐渐增多(P = 0.0006)。未接受 RT 的患者年龄更大(78.76 岁 ± 5.48 比 73.37 岁 ± 3.63,P < 0.01)。RT 的使用与肿瘤分级和大小之间没有差异。接受 SLNB 治疗的患者中(n = 84),仅 3 例(3.5%)淋巴结阳性。在公布 CALGB 9343 数据后(2014-2017 年)治疗的患者的多变量分析中,只有年龄是接受 RT 治疗的预测因素(OR,0.77;95%CI,0.67-0.88)。在适当选择的患者中,临床实践中同时遗漏 RT 和 SLNB 的情况正在增加。随着年龄的增长,患者接受这些干预措施遗漏的可能性增加。低淋巴结阳性率表明这种策略可能未得到充分利用。在这群低危患者中,肿瘤分级和大小并不是遗漏 RT 的预测因素。随着这些方法的广泛应用,需要长期数据。

相似文献

[1]
Increasing omission of radiation therapy and sentinel node biopsy in elderly patients with early stage, hormone-positive breast cancer.

Breast J. 2019-8-25

[2]
Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer.

JAMA Netw Open. 2021-4-1

[3]
Nodal staging affects adjuvant treatment choices in elderly patients with clinically node-negative, estrogen receptor-positive breast cancer.

Curr Oncol. 2020-10

[4]
Utility of Axillary Staging in Older Patients with HER2-Positive Breast Cancer.

Ann Surg Oncol. 2024-10

[5]
Population-based analysis of non-operative management and treatment patterns in older women with estrogen receptor-positive breast cancer.

Breast Cancer Res Treat. 2021-12

[6]
Is axillary lymph node dissection necessary after sentinel lymph node biopsy in patients with mastectomy and pathological N1 breast cancer?

Ann Surg Oncol. 2014-12

[7]
Pre-mastectomy sentinel lymph node biopsy: a strategy to enhance outcomes in immediate breast reconstruction.

Breast J. 2013-6-17

[8]
Impact of CALGB 9343 Trial and Sociodemographic Variation on Patterns of Adjuvant Radiation Therapy Practice for Elderly Women (≥70 Years) with Stage I, Estrogen Receptor-positive Breast Cancer: Analysis of the National Cancer Data Base.

Anticancer Res. 2017-10

[9]
Disparities and trends in sentinel lymph node biopsy among early-stage breast cancer patients (1998-2005).

J Natl Cancer Inst. 2008-4-2

[10]
Trends in axillary treatment for breast cancer patients undergoing sentinel lymph node biopsy as determined by a questionnaire from the Japanese Breast Cancer Society.

Breast Cancer. 2017-5

引用本文的文献

[1]
Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis.

Breast. 2025-8-22

[2]
Breast Cancer in Geriatric Patients: Current Landscape and Future Prospects.

Clin Interv Aging. 2022

[3]
Evaluating the Clinical Utility of Routine Sentinel Lymph Node Biopsy and the Value of Adjuvant Chemotherapy in Elderly Patients Diagnosed With Oestrogen Receptor Positive, Clinically Node Negative Breast Cancer.

Breast Cancer (Auckl). 2021-6-14

[4]
Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer.

JAMA Netw Open. 2021-4-1

[5]
Patients Older 65 Years With Early Breast Cancer Prefer Intraoperative Radiation as a Locoregional Treatment Choice.

Ann Surg Oncol. 2021-9

[6]
Predicting Survival Benefit of Sparing Sentinel Lymph Node Biopsy in Low-Risk Elderly Patients With Early Breast Cancer: A Population-Based Analysis.

Front Oncol. 2020-9-11

[7]
Long-term Impact of CALGB 9343 on Radiation Utilization.

J Surg Res. 2020-12

[8]
Does persistent use of radiation in women > 70 years of age with early-stage breast cancer reflect tailored patient-centered care?

Breast Cancer Res Treat. 2020-3-3

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