Department of Radiology, Liaoning Cancer Hospital & Institute, China Medical University, Shenyang, 110042, Liaoning, China.
Osteoporos Int. 2019 Dec;30(12):2469-2476. doi: 10.1007/s00198-019-05145-w. Epub 2019 Aug 26.
Perfusion of the pelvic bone marrow is reduced in the postmenopausal group and with age. Quantitative dynamic contrast-enhanced MRI could reflect the blood supply characteristics and hemodynamic changes of the pelvic bone marrow. These results contribute to the description of osteoporosis in the postmenopausal females and the elderly.
To investigate the effect of menstrual status and age on the perfusion of pelvic bone marrow in adult females using quantitative dynamic contrast-enhanced MRI (DCE-MRI).
In total, 96 adult females who underwent DCE-MRI between September 2017 and December 2017 were included. All the subjects' quantitative DCE-MRI parameters of pelvic bone marrow were measured and retrospectively analyzed, including K (volume transfer constant), K (efflux rate constant), and V (interstitial volume). According to their menstrual status, the subjects were divided into a premenopausal group (n = 39) and a postmenopausal group (n = 57), and the two groups were then divided into four subgroups according to age. The intraobserver reliability was assessed by the intraclass correlation coefficient (ICC). The parameters were compared between different menstrual status groups and age subgroups by Mann-Whitney test, and Spearman correlation analysis was used to evaluate the correlation between the age and the quantitative parameters.
The ICCs of the K, K, and V values were 0.989, 0.974, and 0.920, respectively. K, K, and V of the premenopausal group were significantly higher than those of the postmenopausal group (P < 0.05). The overall age was negatively correlated with K, K, and V (r = - 0.590, - 0.357, and - 0.381, respectively, P < 0.05). In the premenopausal group, K and V were significantly higher in subgroup 1 (≤ 40 years) compared with subgroup 2 (> 40 years) (P < 0.05), and age showed a negative correlation with K and V (r = - 0.344 and - 0.334, respectively, P < 0.05). In the postmenopausal group, K and K were significantly higher in subgroup 3 (≤ 60 years) compared with subgroup 4 (> 60 years) (P < 0.05), and age showed a negative correlation with K and K (r = - 0.460 and - 0.303, respectively, P < 0.05).
Menstrual status and age have significant effects on the perfusion of the pelvic bone marrow microenvironment in adult females and that the microenvironment of the pelvic bone marrow displays different changes at different age stages. Quantitative DCE-MRI has contributed to the interpretation of the pelvic bone marrow perfusion status.
使用定量动态对比增强磁共振成像（DCE-MRI）研究月经状态和年龄对成年女性骨盆骨髓灌注的影响。
本研究共纳入 96 名于 2017 年 9 月至 2017 年 12 月期间接受 DCE-MRI 检查的成年女性。测量并回顾性分析所有受试者的骨盆骨髓定量 DCE-MRI 参数，包括 K（容积转移常数）、K（流出率常数）和 V（间质容积）。根据月经状态，将受试者分为绝经前组（n=39）和绝经后组（n=57），然后根据年龄将两组再分为 4 个亚组。采用组内相关系数（ICC）评估观察者内信度。采用 Mann-Whitney 检验比较不同月经状态组和年龄亚组之间的参数，采用 Spearman 相关分析评估年龄与定量参数之间的相关性。
K、K 和 V 值的 ICC 分别为 0.989、0.974 和 0.920。绝经前组的 K、K 和 V 值明显高于绝经后组（P<0.05）。总体年龄与 K、K 和 V 呈负相关（r=-0.590、-0.357 和-0.381，P<0.05）。在绝经前组中，年龄≤40 岁的亚组 1 中 K 和 V 值明显高于年龄>40 岁的亚组 2（P<0.05），且年龄与 K 和 V 呈负相关（r=-0.344 和-0.334，P<0.05）。在绝经后组中，年龄≤60 岁的亚组 3 中 K 和 K 值明显高于年龄>60 岁的亚组 4（P<0.05），且年龄与 K 和 K 呈负相关（r=-0.460 和-0.303，P<0.05）。
月经状态和年龄对成年女性骨盆骨髓微环境的灌注有显著影响，骨盆骨髓的微环境在不同年龄段呈现出不同的变化。定量 DCE-MRI 有助于解释骨盆骨髓的灌注状态。
