绷带式角膜接触镜佩戴者感染性角膜炎的特征。

Characteristics of Infectious Keratitis in Bandage Contact Lens Wear Patients.

机构信息

Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Eye Contact Lens. 2019 Nov;45(6):356-359. doi: 10.1097/ICL.0000000000000593.

DOI:10.1097/ICL.0000000000000593

PMID:31453822

Abstract

OBJECTIVE

The aim of this study was to determine the characteristics of infectious keratitis in patients wearing bandage contact lenses (BCLs).

METHODS

The BCL-related infectious keratitis cases were reviewed at the eye center of the Second Affiliated Hospital at the Zhejiang University School of Medicine from January 2015 to August 2018. Detailed information about the patients with infectious keratitis was collected, including the age, gender, clinical characteristics, culture results, and other measures. All the data analyses were performed using IBM SPSS Statistics for Windows version 24.0.

RESULTS

From January 2015 until August 2018, 6,385 eyes of 6,188 patients, including 3,410 males and 2,778 females, received BCLs at our hospital. The mean age of these patients was 48.10±20.81 years (range=15-78 years). The mean BCL wearing time was 18.98±23.72 days (range=1-58 days). Eight patients (0.13%) with infectious keratitis were identified, and the mean age of these patients was 54.33±28.14 years (range=16-75 years). Seven of the infectious keratitis patients were older than 50 years, and one patient was 16 years old. The infectious keratitis incidence rate of the older patients (≥50 years) was significantly higher than that of the young patients (<50 years) (χ=9.647, P=0.002). There was a higher postkeratoplasty risk of BCL-related infectious keratitis than that in the corneal epithelial defect (χ=21.371, P=0.000) and pterygium surgery (χ=16.037, P=0.000) cases, but not in the corneal collagen cross-linking cases (χ=1.792, P=0.181). The mean onset time of BCL-related infectious keratitis was 22.63±18.72 days (range=3-58 days) after wearing the BCLs. Among these 8 infected patients, 3 were noncompliant with their eye drop use and 2 extended their BCL wearing time past 30 days.

CONCLUSION

Bandage CL-related infectious keratitis is more likely to occur in older patients. The most common risk factor for BCL-related infectious keratitis was postkeratoplasty use. Overall, appropriate indications, good compliance, and close follow-up attention are required for BCL wearers.

摘要

目的

本研究旨在确定佩戴绷带接触镜（BCL）患者感染性角膜炎的特征。

方法

回顾 2015 年 1 月至 2018 年 8 月期间浙江大学医学院附属第二医院眼科中心的 BCL 相关感染性角膜炎病例。收集了感染性角膜炎患者的详细信息，包括年龄、性别、临床特征、培养结果和其他措施。所有数据分析均使用 IBM SPSS Statistics for Windows 版本 24.0 进行。

结果

从 2015 年 1 月至 2018 年 8 月，我院共有 6188 名患者的 6385 只眼佩戴了 BCL，其中男性 3410 只眼，女性 2778 只眼。这些患者的平均年龄为 48.10±20.81 岁（范围为 15-78 岁）。这些患者的平均 BCL 佩戴时间为 18.98±23.72 天（范围为 1-58 天）。共发现 8 例（0.13%）感染性角膜炎患者，这些患者的平均年龄为 54.33±28.14 岁（范围为 16-75 岁）。7 例感染性角膜炎患者年龄大于 50 岁，1 例患者年龄为 16 岁。老年患者（≥50 岁）的感染性角膜炎发病率明显高于年轻患者（<50 岁）（χ=9.647，P=0.002）。与角膜上皮缺损（χ=21.371，P=0.000）和翼状胬肉手术（χ=16.037，P=0.000）相比，角膜移植术后佩戴 BCL 更易发生 BCL 相关感染性角膜炎，但与角膜胶原交联术（χ=1.792，P=0.181）无关。8 例 BCL 相关感染性角膜炎患者佩戴 BCL 后，平均发病时间为 22.63±18.72 天（范围为 3-58 天）。在这 8 例感染患者中，有 3 例不遵医嘱滴用眼药水，2 例延长了 BCL 的佩戴时间超过 30 天。