脂滴与疾病
Lipid Droplets in Disease.
机构信息
Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996-2200, USA.
出版信息
Cells. 2019 Aug 26;8(9):974. doi: 10.3390/cells8090974.
Abstract
Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer's disease, cardiovascular disease, and cancer [...].
摘要
脂滴（LDs）是脂质储存的重要组成部分；因此，它们是受脂质失衡影响的各种疾病（如肥胖、脂肪肝疾病、2 型糖尿病、阿尔茨海默病、心血管疾病和癌症等）的重要参与者[... ]。
相似文献
1
Lipid Droplets in Disease.脂滴与疾病
Cells. 2019 Aug 26;8(9):974. doi: 10.3390/cells8090974.
2
Acute exercise increases the contact between lipid droplets and mitochondria independently of obesity and type 2 diabetes.急性运动增加了脂滴和线粒体之间的接触，与肥胖和 2 型糖尿病无关。
J Physiol. 2023 May;601(10):1797-1815. doi: 10.1113/JP284386. Epub 2023 Apr 17.
3
Hepatic lipid droplet biology: Getting to the root of fatty liver.肝脏脂质滴生物学：探寻脂肪肝的根源
Hepatology. 2015 Sep;62(3):964-7. doi: 10.1002/hep.27839. Epub 2015 May 9.
4
Lipid Droplet Formation and Lipophagy in Fatty Liver Disease.脂滴形成和脂噬在脂肪肝疾病中的作用。
Semin Liver Dis. 2019 Jul;39(3):283-290. doi: 10.1055/s-0039-1685524. Epub 2019 Apr 30.
5
Control of lipid droplet fusion and growth by CIDE family proteins.CIDE 家族蛋白对脂滴融合和生长的调控。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1197-1204. doi: 10.1016/j.bbalip.2017.06.009. Epub 2017 Jun 23.
6
Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.线粒体与脂滴结合：线粒体动态调节脂质储存和利用的地方。
Cell Metab. 2019 Apr 2;29(4):827-835. doi: 10.1016/j.cmet.2019.02.011. Epub 2019 Mar 21.
7
Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.饮食脂肪吸收的最新发现：肠细胞内细胞质脂滴的存在、合成及代谢
Biochim Biophys Acta. 2016 Aug;1861(8 Pt A):730-47. doi: 10.1016/j.bbalip.2016.04.012. Epub 2016 Apr 20.
8
A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis.脂质滴代谢的统一数学模型揭示了肝脂肪变性发展中的关键分子参与者。
FEBS J. 2017 Oct;284(19):3245-3261. doi: 10.1111/febs.14189. Epub 2017 Sep 6.
9
Lipid Droplets: Formation to Breakdown.脂滴：从形成到分解
Lipids. 2017 Jun;52(6):465-475. doi: 10.1007/s11745-017-4263-0. Epub 2017 May 20.
10
Altered intramuscular network of lipid droplets and mitochondria in type 2 diabetes.2 型糖尿病患者肌内脂滴和线粒体网络的改变。
Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C39-C57. doi: 10.1152/ajpcell.00470.2022. Epub 2022 Nov 21.
引用本文的文献
1
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses.载脂蛋白E4重塑脂滴蛋白质组并调节小胶质细胞炎症反应。
Neurobiol Dis. 2025 Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. Epub 2025 May 30.
2
Polarity-sensitive dual emissive fluorescent carbon dots as highly specific targeting probes for lipid droplets in live cells.极性敏感的双发射荧光碳点作为活细胞中脂滴的高特异性靶向探针。
Nanoscale Adv. 2025 Mar 18;7(9):2686-2694. doi: 10.1039/d5na00061k. eCollection 2025 Apr 29.
3
Serum lipidomic changes and sex differences in androgenetic alopecia.雄激素性脱发中的血清脂质组学变化及性别差异
Heliyon. 2024 Feb 13;10(4):e26204. doi: 10.1016/j.heliyon.2024.e26204. eCollection 2024 Feb 29.
4
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.硫化氢通过 Hrd1 S-巯基化减少 db/db 小鼠心脏组织中脂滴的积累。
J Cell Mol Med. 2021 Oct;25(19):9154-9167. doi: 10.1111/jcmm.16781. Epub 2021 Sep 25.
5
Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment.脂肪自噬：天然产物在2型糖尿病治疗中的新视角
Diabetes Metab Syndr Obes. 2021 Jun 30;14:2985-2999. doi: 10.2147/DMSO.S310166. eCollection 2021.
6
A Novel Photosensitizer for Lipid Droplet-Location Photodynamic Therapy.一种用于脂滴定位光动力疗法的新型光敏剂。
Front Chem. 2021 Jun 14;9:701771. doi: 10.3389/fchem.2021.701771. eCollection 2021.
7
Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure.Seipin 在其环状结构中积累和捕获二酰基甘油和三酰基甘油。
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). doi: 10.1073/pnas.2017205118.
8
Automated lipid droplet quantification system for phenotypic analysis of adipocytes using CellProfiler.基于 CellProfiler 的自动化脂滴定量系统用于脂肪细胞表型分析。
Toxicol Mech Methods. 2020 Jun;30(5):378-387. doi: 10.1080/15376516.2020.1747124. Epub 2020 Apr 8.
本文引用的文献
1
Characterization of Lipid and Lipid Droplet Metabolism in Human HCC.人肝癌中脂质和脂滴代谢的特征。
Cells. 2019 May 27;8(5):512. doi: 10.3390/cells8050512.
2
Lipid Droplets: A Significant but Understudied Contributor of Host⁻Bacterial Interactions.脂滴：宿主-细菌相互作用的一个重要但研究不足的贡献者。
Cells. 2019 Apr 15;8(4):354. doi: 10.3390/cells8040354.
3
4
Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice.熊去氧胆酸调节瘦素缺乏肥胖小鼠肝脏能量稳态和白色脂肪组织巨噬细胞极化。
Cells. 2019 Mar 16;8(3):253. doi: 10.3390/cells8030253.
5
Skeletal Muscle Lipid Droplets and the Athlete's Paradox.骨骼肌脂滴与运动员悖论。
Cells. 2019 Mar 15;8(3):249. doi: 10.3390/cells8030249.
6
CIDE Proteins in Human Health and Disease.CIDE 蛋白与人类健康和疾病
Cells. 2019 Mar 13;8(3):238. doi: 10.3390/cells8030238.
7
Neutral Lipid Storage Diseases as Cellular Model to Study Lipid Droplet Function.中性脂质贮积病作为研究脂滴功能的细胞模型。
Cells. 2019 Feb 21;8(2):187. doi: 10.3390/cells8020187.
8
Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation.载脂蛋白 E4 改变星形胶质细胞脂肪酸代谢和脂滴形成。
Cells. 2019 Feb 20;8(2):182. doi: 10.3390/cells8020182.
9
ETF-QO Mutants Uncoupled Fatty Acid β-Oxidation and Mitochondrial Bioenergetics Leading to Lipid Pathology.ETF-QO 突变体使脂肪酸β氧化和线粒体生物能解偶联，导致脂质病变。
Cells. 2019 Jan 31;8(2):106. doi: 10.3390/cells8020106.
10
Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis.脂滴表面磷脂酰胆碱的减少与蛋白质结合改变和脂肪变性相关。
Cells. 2018 Nov 24;7(12):230. doi: 10.3390/cells7120230.
Zotero 插件