Reddy M M, Sorrell S J, Lange M, Grieco M H
R. A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital Center, New York, NY 10019.
J Acquir Immune Defic Syndr (1988). 1988;1(5):436-40.
Tumor necrosis factor (TNF) and HIV P24 antigen levels were determined in the serum of intravenous drug abusers (IVDAs), homosexuals, and patients with lymphadenopathy or acquired immune deficiency syndrome (AIDS). The mean TNF level in the serum of normal controls was 12 +/- 5 compared to 112 +/- 25 pg/ml in the serum of HIV-seronegative asymptomatic IVDAs. This increase of TNF may be due to the variety of infections that these people are exposed to persistently. The mean TNF level in the serum of HIV-seropositive asymptomatic IVDAs was 112 +/- 79 pg/ml, 31 +/- 24 pg/ml in lymphadenopathy, and 55 +/- 19 pg/ml in patients with AIDS. The mean P24 level in the serum of patients with AIDS was 50 +/- 13 pg/ml compared to 0 pg/ml in HIV-seronegative subjects, while the other HIV-seropositive groups had relatively low levels. The P24 antigen levels may reflect viral load in these patients. SIL-2R and beta2-microglobulin levels were also elevated in patients with HIV infection . The TNF may play a role in the antiviral activity against HIV virus and in the development of full-blown disease after HIV infection.
测定了静脉吸毒者、同性恋者以及患有淋巴结病或获得性免疫缺陷综合征（AIDS）患者血清中的肿瘤坏死因子（TNF）和HIV P24抗原水平。正常对照血清中的TNF平均水平为12±5，而HIV血清阴性无症状静脉吸毒者血清中的TNF平均水平为112±25 pg/ml。TNF的这种升高可能是由于这些人持续暴露于多种感染所致。HIV血清阳性无症状静脉吸毒者血清中的TNF平均水平为112±79 pg/ml，淋巴结病患者为31±24 pg/ml，AIDS患者为55±19 pg/ml。AIDS患者血清中的P24平均水平为50±13 pg/ml，而HIV血清阴性受试者为0 pg/ml，其他HIV血清阳性组的水平相对较低。P24抗原水平可能反映了这些患者的病毒载量。HIV感染患者的可溶性白细胞介素-2受体（SIL-2R）和β2-微球蛋白水平也升高。TNF可能在针对HIV病毒的抗病毒活性以及HIV感染后全面疾病的发展中发挥作用。
