Internal Medicine Department, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
In Vivo. 2019 Sep-Oct;33(5):1425-1430. doi: 10.21873/invivo.11620.
BACKGROUND/AIM: Streptococcus pneumoniae is the leading cause of bacterial pneumonia and an important cause of invasive disease. Despite the antiretroviral therapies, adults infected with human immunodeficiency virus (HIV) are at particular risk for invasive pneumococcal disease (IPD). The purpose of this study was to report the efficacy of the strategies currently being used in pneumococcal vaccination for HIV-infected adults.
A literature search was performed through electronic databases, for original articles in English, from years 2000 to 2019. Clinical trials controlled or randomized, and cohort studies were included.
While 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for immunocompromised patients, it has been reported that it is less suitable for HIV-infected patients. Recent guidelines have added pneumococcal conjugate vaccine (PCV) to the list of recommended vaccines.
Further studies are needed to determine the optimal vaccines and intervals for subsequent revaccinations during the lifetime.
背景/目的:肺炎链球菌是细菌性肺炎的主要病因,也是侵袭性疾病的重要病因。尽管有抗逆转录病毒疗法,但感染人类免疫缺陷病毒 (HIV) 的成年人尤其容易罹患侵袭性肺炎球菌病 (IPD)。本研究的目的是报告目前用于 HIV 感染成年人肺炎球菌疫苗接种的策略的疗效。
通过电子数据库对 2000 年至 2019 年的英文原始文章进行了文献检索。纳入了对照或随机临床试验和队列研究。
虽然 23 价肺炎球菌多糖疫苗 (PPV23) 被推荐用于免疫功能低下的患者,但有报道称其对 HIV 感染患者不太适用。最近的指南已将肺炎球菌结合疫苗 (PCV) 添加到推荐疫苗清单中。
需要进一步研究以确定在一生中最佳的疫苗和后续加强免疫的间隔。