Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
Department of Biomedical Engineering, University of Melbourne, Melbourne, Australia.
Bone. 2019 Dec;129:115051. doi: 10.1016/j.bone.2019.115051. Epub 2019 Aug 28.
Dual energy X-ray absorptiometry, the current clinical criterion method for osteoporosis diagnosis, has limitations in identifying individuals with increased fracture risk, especially at the distal radius. Peripheral quantitative computed tomography (pQCT) can provide volumetric bone density data, as well as information on bone geometry, which makes it possible to establish finite element (FE) models of the distal radius from which bone strength and stiffness can be calculated. In this study, we compared experimental mechanical failure load data of the forearm with pQCT- based FE (pQCT-FE) modelling properties. Sixteen cadaveric forearm specimens were experimentally loaded until failure. Estimated stiffness and strength variables of compression, shear, bending and torsion were calculated from pQCT-FE modelling of single cross-sections of 0.2 × 0.2 × 2.4 mm of the radius pQCT image. A moderate-to-strong coefficient of determination (r) was observed between experimental failure load and pQCT-FE variables. The highest r was observed for bending stiffness (r = 0.83). This study validates the use of pQCT-FE in the assessment of distal radius bone strength for future studies.
双能 X 射线吸收法是目前用于骨质疏松症诊断的临床标准方法，但在识别骨折风险增加的个体方面存在局限性，尤其是在桡骨远端。外周定量计算机断层扫描 (pQCT) 可以提供容积骨密度数据以及骨几何结构信息，从而可以建立桡骨远端的有限元 (FE) 模型，从中可以计算骨强度和刚度。在这项研究中，我们比较了前臂的实验力学失效载荷数据与基于 pQCT 的 FE(pQCT-FE)建模特性。对 16 个尸体前臂标本进行了实验加载，直至失效。从桡骨 pQCT 图像的 0.2×0.2×2.4mm 单个横截面的 pQCT-FE 建模中计算了压缩、剪切、弯曲和扭转的估计刚度和强度变量。实验失效载荷与 pQCT-FE 变量之间观察到中等至强的决定系数 (r)。弯曲刚度的 r 值最高(r=0.83)。这项研究验证了 pQCT-FE 在未来研究中评估桡骨远端骨强度的用途。
