Department of Cardiovascular Surgery, University Hospital Freiburg Cardiac Centre Freiburg Bad Krozingen Freiburg Branch, Freiburg, Germany
Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.
BMJ Open. 2019 Aug 30;9(8):e030562. doi: 10.1136/bmjopen-2019-030562.
Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly applied in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) patients. Treatment results are promising, but the efficacy and safety of the procedure are still unclear. Currently, there are no recommended target perfusion parameters during eCPR, the lack of which could result in inadequate (re)perfusion. We aim to perform a scoping review to explore the current literature addressing target perfusion parameters, target values, corresponding survival rates and neurologic outcomes in OHCA and IHCA patients treated with eCPR.
To identify relevant research, we will conduct searches in the electronic databases MEDLINE, EMBASE, Social Science Citation Index, Social Science Citation Index Expanded and the Cochrane library. We will also check references of relevant articles and perform a cited reference research (forward citation tracking).Two independent reviewers will screen titles and abstracts, check full texts for eligibility and perform data extraction. We will resolve dissent by consensus, moderated by a third reviewer. We will include observational and controlled studies addressing target perfusion parameters and outcomes such as survival rates and neurologic findings in OHCA and IHCA patients treated with eCPR. Data extraction tables will be set up, including study and patients' characteristics, aim of study, details on eCPR including target perfusion parameters and reported outcomes. We will summarise the data using tables and figures (ie, bubble plot) to present the research landscape and to describe potential clusters and/or gaps.
An ethical approval is not needed. We intend to publish the scoping review in a peer-reviewed journal and present results on a scientific meeting.
体外心肺复苏（eCPR）越来越多地应用于院外心脏骤停（OHCA）和院内心脏骤停（IHCA）患者。治疗效果令人鼓舞，但该程序的疗效和安全性仍不清楚。目前，eCPR 过程中没有推荐的目标灌注参数，这可能导致灌注不足（再）。我们旨在进行范围综述，以探讨目前关于接受 eCPR 治疗的 OHCA 和 IHCA 患者的目标灌注参数、目标值、相应生存率和神经结局的文献。
为了确定相关研究，我们将在电子数据库 MEDLINE、EMBASE、社会科学引文索引、社会科学引文索引扩展版和 Cochrane 图书馆中进行搜索。我们还将检查相关文章的参考文献，并进行引文研究（正向引文追踪）。两名独立的审查员将筛选标题和摘要，检查全文的资格并进行数据提取。我们将通过共识解决分歧，由第三名审查员进行调解。我们将包括观察性和对照研究，以确定接受 eCPR 治疗的 OHCA 和 IHCA 患者的目标灌注参数和结局，如生存率和神经学发现。将设置数据提取表，包括研究和患者特征、研究目的、eCPR 细节，包括目标灌注参数和报告的结果。我们将使用表格和图形（即气泡图）总结数据，以展示研究概况并描述潜在的集群和/或差距。
不需要伦理批准。我们打算将范围综述发表在同行评议的期刊上，并在科学会议上展示结果。
