长期抗癫痫治疗对脑干听觉诱发电位的影响。

Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.

作者信息

Medaglini S, Filippi M, Smirne S, Ferini-Strambi L, Giusti M C, Poggi A, Comi G

机构信息

Scientific Institute H.S. Raffaele, Neurologic Department, University of Milan, Italy.

出版信息

Neuropsychobiology. 1988;19(2):104-7. doi: 10.1159/000118443.

DOI:10.1159/000118443

PMID:3147408

Abstract

The brainstem auditory evoked potentials of 84 epileptic patients in chronic monotherapy with carbamazepine (n = 36), phenobarbital (n = 19), Na-valproate (n = 20) or progabide (n = 9) were studied. The mean values of I-III and I-V interpeak latencies (IPLs) were respectively 2.16 +/- 0.11 and 4.03 +/- 0.17 in the control group, 2.31 +/- 0.09 and 4.17 +/- 0.16 in the valproic group, 2.30 +/- 0.17 and 4.19 +/- 0.20 in the carbamazepine group, 2.17 +/- 0.16 and 4.10 +/- 0.18 in the phenobarbital group and 2.16 +/- 0.11 and 4.12 +/- 0.17 in the progabide group. The prolongation of I-III and I-V IPLs was statistically significant only for the valproic acid and carbamazepine groups. Neither duration of the epilepsy and treatment and frequency of seizures nor the serum drug levels were correlated with I-V IPL values.

摘要

对84例接受卡马西平（n = 36）、苯巴比妥（n = 19）、丙戊酸钠（n = 20）或普罗加比（n = 9）慢性单一疗法治疗的癫痫患者的脑干听觉诱发电位进行了研究。对照组I-III和I-V峰间潜伏期（IPL）的平均值分别为2.16±0.11和4.03±0.17，丙戊酸组为2.31±0.09和4.17±0.16，卡马西平组为2.30±0.17和4.19±0.20，苯巴比妥组为2.17±0.16和4.10±0.18，普罗加比组为2.16±0.11和4.12±0.17。仅丙戊酸组和卡马西平组的I-III和I-V IPL延长具有统计学意义。癫痫病程、治疗时间、癫痫发作频率以及血清药物水平均与I-V IPL值无关。