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磁括约肌增强术:肥胖症手术后症状性反流的可行挽救性治疗方法。

Magnetic sphincter augmentation: a viable rescue therapy for symptomatic reflux following bariatric surgery.

机构信息

Division of Minimally Invasive Surgery, Center for the Future of Surgery, University of California of San Diego, MET Building, Lower Level, 9500 Gilman Drive MC 0740, La Jolla, CA, 92093-0740, USA.

Esophageal Institute of Atlanta, Atlanta, GA, USA.

出版信息

Surg Endosc. 2020 Jul;34(7):3211-3215. doi: 10.1007/s00464-019-07096-z. Epub 2019 Sep 4.

Abstract

INTRODUCTION

Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) are commonly performed bariatric procedures in obesity management. Gastroesophageal reflux disease (GERD) in this population has reported rates of 23-100%. GERD after LSG has been noted with recent studies demonstrating de novo reflux or symptom exacerbation despite weight loss. Fundoplication is not an option, and medically refractory GERD after LSG is usually treated with conversion to RYGB. GERD post-RYGB is a unique entity, and management poses a clinical and technical challenge. We evaluate safety and effectiveness of magnetic sphincter augmentation after bariatric surgery.

MATERIALS AND METHODS

A retrospective review of a prospectively maintained database was performed identifying patients that underwent LINX placement for refractory GERD after LSG, LRYGB, or duodenal switch across three institutions. Outcomes included complications, length of stay, PPI use, GERD-HRQL scores, and patient overall satisfaction.

RESULTS

From March 2014 through June 2018, 13 identified patients underwent LINX placement after bariatric surgery: 8 LSG, 4 LRYGB, and 1 duodenal switch. The patients were 77% female, with mean age 43 and average BMI 30.1. Average pre-operative DeMeester score was 24.8. Pre-operatively, 5 patients were on daily PPI, 6 on BID PPI, and 1 on PPI + H2 blocker. We noted decreased medication usage post-operatively, with 4 patients taking daily PPI, and 9 off medication completely. A GERD-HRQL score was obtained pre- and post-operatively in 6 patients with average reduction from 25 to 8.5 (p value 0.002). Two patients experienced complications requiring endoscopic dilation after LINX placement. 100% of patients reported overall satisfaction post procedure.

CONCLUSION

LINX placement is a safe, effective treatment option for surgical management of refractory GERD after bariatric surgery. It can relieve symptoms and obviate the requirement of high-dose medical management. Magnetic lower esophageal sphincter augmentation should be another tool in the surgeon's toolbox for managing reflux after bariatric surgery in select patients.

摘要

简介

腹腔镜袖状胃切除术(LSG)和腹腔镜 Roux-en-Y 胃旁路术(LRYGB)是肥胖症管理中常用的减重手术。该人群中胃食管反流病(GERD)的报告率为 23-100%。最近的研究表明,LSG 后会出现新的反流或症状加重,尽管体重有所减轻。胃底折叠术不是一种选择,LSG 后药物难治性 GERD 通常采用转为 RYGB 治疗。RYGB 后 GERD 是一种独特的实体,其管理具有临床和技术挑战。我们评估了减重手术后磁括约肌增强术的安全性和有效性。

材料和方法

对三家机构前瞻性维护的数据库进行回顾性分析,确定因 LSG、LRYGB 或十二指肠转流术后难治性 GERD 而接受 LINX 放置的患者。结果包括并发症、住院时间、PPI 使用、GERD-HRQL 评分和患者总体满意度。

结果

2014 年 3 月至 2018 年 6 月,13 例患者在减重手术后接受 LINX 放置:8 例 LSG、4 例 LRYGB 和 1 例十二指肠转流术。患者中女性占 77%,平均年龄 43 岁,平均 BMI 为 30.1。术前平均 DeMeester 评分 24.8。术前,5 例患者每日服用 PPI,6 例患者每日服用 2 次 PPI,1 例患者同时服用 PPI 和 H2 阻滞剂。我们注意到术后药物使用减少,4 例患者每日服用 PPI,9 例患者完全停药。6 例患者在术前和术后获得 GERD-HRQL 评分,平均从 25 分降至 8.5 分(p 值<0.002)。2 例患者在 LINX 放置后出现需要内镜扩张的并发症。100%的患者对术后情况表示满意。

结论

LINX 放置是治疗减重手术后难治性 GERD 的安全、有效治疗选择。它可以缓解症状,避免高剂量药物治疗的需要。对于某些患者,磁括约肌增强术应该成为外科医生治疗减重手术后反流的另一种工具。

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