Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy -
Department of Internal Medicine and Geriatrics, Italian National Research Center on Ageing (IRCCS INRCA), Ancona, Italy -
Minerva Anestesiol. 2020 Mar;86(3):261-269. doi: 10.23736/S0375-9393.19.13896-5. Epub 2019 Sep 3.
General anesthesia is associated with high morbidity/mortality in comorbid older adults. Thoracic continuous spinal anesthesia/analgesia (TCSA) may be an alternative for major abdominal surgery. We report a one-year experience of the use of TCSA in an Italian geriatric center.
Retrospective review of case notes of high-risk older patients (ASA class ≥III) who underwent TCSA for major abdominal surgery between May 2017-May 2018. TCSA was performed with a 21-gauge Tuohy-shaped spinal needle and a 24-gauge catheter (level of insertion between T6-7 and T10-11). Hyperbaric bupivacaine or levobupivacaine (two boluses of 2.5 mg) plus fentanyl (10-25 µg) were injected before incision, followed by additional doses if needed. Intrathecal levobupivacaine plus fentanyl were infused for 72 hours after surgery. We described the anesthesiologic management and evaluated the incidence of postoperative complications.
Ninety patients (age 84.4±6.9 years, 53.3% male) were enrolled. High comorbidity, according to the Geriatric Index of Comorbidity, was found in 64.4% of the patients. Mean Metabolic Equivalents were 2.58±0.99. Switching to general anesthesia was required in one case. Intraoperative noradrenaline (0.17±0.12 mcg/kg/min) was required in 70.6%. Additional intravenous paracetamol or weak opioids were required in 23% and 2.2% of patients, respectively. No direct complications of TCSA were reported. Cardiac, respiratory and surgical complications occurred in 15.6%, 13.3% and 13.3% of patients, respectively. Delirium occurred in 14.4%. Hospital mortality was 5.6%.
TCSA may be a valid alternative to general anesthesia in high-risk older patients undergoing major abdominal surgery. Further studies are needed to confirm its safety and benefits.
全身麻醉与合并症老年患者的高发病率/死亡率相关。胸椎连续脊髓麻醉/镇痛(TCSA)可能是腹部大手术的替代方法。我们报告了一家意大利老年医学中心使用 TCSA 的一年经验。
回顾性分析 2017 年 5 月至 2018 年 5 月期间因腹部大手术接受 TCSA 的高危老年患者(ASA 分级≥III 级)的病历。TCSA 使用 21 号 Tuohy 形脊髓针和 24 号导管(插入水平在 T6-7 和 T10-11 之间)进行。在切口前注射布比卡因或左旋布比卡因(2.5mg 两剂)加芬太尼(10-25μg),如有需要则追加剂量。手术后 72 小时内输注鞘内左旋布比卡因加芬太尼。我们描述了麻醉管理并评估了术后并发症的发生率。
共纳入 90 例患者(年龄 84.4±6.9 岁,53.3%为男性)。根据老年合并症指数,64.4%的患者存在高合并症。平均代谢当量为 2.58±0.99。1 例需要转为全身麻醉。70.6%的患者需要术中去甲肾上腺素(0.17±0.12 mcg/kg/min)。分别有 23%和 2.2%的患者需要额外静脉注射扑热息痛或弱阿片类药物。未报告 TCSA 的直接并发症。心脏、呼吸和手术并发症分别发生在 15.6%、13.3%和 13.3%的患者中。14.4%的患者发生谵妄。住院死亡率为 5.6%。
TCSA 可能是高危老年患者行腹部大手术的全身麻醉的有效替代方法。需要进一步的研究来确认其安全性和益处。