海马中的干细胞异质性。

Heterogeneity of Stem Cells in the Hippocampus.

机构信息

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.

Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA.

出版信息

Adv Exp Med Biol. 2019;1169:31-53. doi: 10.1007/978-3-030-24108-7_2.

DOI:10.1007/978-3-030-24108-7_2

PMID:31487017

Abstract

The discovery of neural stem cells in the adult mammalian hippocampus has attracted attention and controversy, which both continue to this day. Hippocampal neural stem cells and their immediate progeny, amplifying neuroprogenitor cells, give rise to neurons and astrocytes in the region. Envisioned as possible key for tissue regeneration, whether mobilized endogenously or transplanted exogenously, neural stem cells have been in the eye of both public and science over the course of the past 20 years. These cells are a heterogeneous population, and here, we review different aspects of their heterogeneity from morphology to metabolism and response to different stimuli.

摘要

成年哺乳动物海马中的神经干细胞的发现引起了关注和争议，至今仍在继续。海马神经干细胞及其直接后代扩增神经前体细胞在该区域产生神经元和星形胶质细胞。作为组织再生的可能关键，无论是内源性动员还是外源性移植，神经干细胞在过去 20 年中一直是公众和科学界关注的焦点。这些细胞是一个异质群体，在这里，我们从形态到代谢以及对不同刺激的反应等方面综述了它们异质性的不同方面。