Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Pregnancy Hypertens. 2019 Jul;17:144-147. doi: 10.1016/j.preghy.2019.06.005. Epub 2019 Jun 19.
We aimed to study the long-term effect of preeclampsia on the risk for subsequent gastrointestinal morbidity of the offspring.
A population based cohort analysis comparing total and different subtypes of gastrointestinal related pediatric hospitalizations among offspring of preeclamptic mothers versus offspring of mothers without preeclampsia. The analysis included all singletons born between the years 1999-2014 at a single tertiary regional medical center. Gastrointestinal related morbidities included hospitalizations involving a set of ICD-9 codes, as recorded in hospital files. Infants with congenital malformations, multiple gestations, and perinatal deaths were excluded from the analysis. A Kaplan-Meier survival curve was used to compare the cumulative morbidity, and a Cox proportional hazards model was constructed to adjust for confounders.
The study population included 239,687 newborns who met inclusion criteria; among them 2222 (0.93%) were born to mothers with severe preeclampsia or eclampsia, and 7279 (3.03%) were born to mothers with mild preeclampsia. Offspring of mothers with severe preeclampsia had significantly higher rates of gastrointestinal-related hospitalizations in comparison to offspring of mothers with mild preeclampsia and offspring of non-preeclamptic mothers (7.7% vs. 5.5% vs. 5.3%, respectively; p < 0.001). The association between exposure to severe preeclampsia and eclampsia and long-term gastrointestinal morbidity of the offspring remained significant and independent while adjusting for confounders (Adjusted HR = 1.2, 95% CI 1.0-1.4; p = 0.019).
Severe preeclampsia and eclampsia are independent risk factors for pediatric gastrointestinal morbidity of the offspring.
研究子痫前期对后代随后发生胃肠道疾病风险的长期影响。
本研究采用基于人群的队列分析，比较子痫前期母亲的后代与无子痫前期母亲的后代在儿科因胃肠道相关疾病住院的总人数和不同亚型人数。该分析包括 1999 年至 2014 年间在一家三级区域性医疗中心出生的所有单胎。胃肠道相关疾病包括在医院档案中记录的一套 ICD-9 编码的住院治疗。患有先天性畸形、多胎妊娠和围产儿死亡的婴儿被排除在分析之外。采用 Kaplan-Meier 生存曲线比较累积发病率，并构建 Cox 比例风险模型来调整混杂因素。
研究人群包括 239687 名符合纳入标准的新生儿；其中 2222 名（0.93%）母亲患有严重子痫前期或子痫，7279 名（3.03%）母亲患有轻度子痫前期。与轻度子痫前期母亲和非子痫前期母亲的后代相比，严重子痫前期母亲的后代胃肠道相关住院率显著更高（分别为 7.7%、5.5%和 5.3%；p<0.001）。在校正混杂因素后，暴露于严重子痫前期和子痫与后代长期胃肠道疾病发病率之间的关联仍然显著且独立（调整后的 HR=1.2，95%CI 1.0-1.4；p=0.019）。
严重子痫前期和子痫是后代儿科胃肠道疾病的独立危险因素。
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