USP8、HMGA和非编码RNA在垂体肿瘤发生中的新作用。
Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis.
作者信息
D'Angelo Daniela, De Martino Marco, Arra Claudio, Fusco Alfredo
机构信息
Istituto di Endocrinologia ed Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", 80131 Naples, Italy.
Dipartimento di Psicologia, Università della Campania, 81100 Caserta, Italy.
出版信息
Cancers (Basel). 2019 Sep 4;11(9):1302. doi: 10.3390/cancers11091302.
Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the and genes in most of the pituitary tumors. Moreover, deregulated expression of the non-coding RNAs has been very frequently observed in this neoplasia. The aim of this review is to better elucidate the role, the mechanisms, and the possible clinical impact of these novel alterations in the development of pituitary neoplasia.
最近发现了两种在垂体肿瘤发生中起驱动作用的新分子机制。它们是：(a) 促肾上腺皮质激素细胞肿瘤中泛素特异性蛋白酶8（USP8）基因的突变，以及 (b) 大多数垂体肿瘤中 和 基因的过表达。此外，在这种肿瘤中经常观察到非编码RNA的表达失调。本综述的目的是更好地阐明这些新改变在垂体肿瘤发生发展中的作用、机制及可能的临床影响。
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