12周中等强度运动训练对2型糖尿病患者血糖反应的影响：一项前瞻性纵向研究。
Effects of a 12-week moderate-intensity exercise training on blood glucose response in patients with type 2 diabetes: A prospective longitudinal study.
作者信息
Chiang Shang-Lin, Heitkemper Margaret McLean, Hung Yi-Jen, Tzeng Wen-Chii, Lee Meei-Shyuan, Lin Chia-Huei
机构信息
School of Medicine, National Defense Medical Center; Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Taipei, Taiwan, ROC.
Department of Biobehavioral Nursing and Health Systems, Division of Gastroenterology, School of Medicine, University of Washington, USA.
出版信息
Medicine (Baltimore). 2019 Sep;98(36):e16860. doi: 10.1097/MD.0000000000016860.
BACKGROUND
The blood glucose response to moderate-intensity exercise remains unclear for patients with type 2 diabetes (T2DM). In addition, little is known about determinants of blood glucose response to a 12-week moderate-intensity exercise training. Therefore, this study aimed to explore trends in blood glucose in response to a 12-week moderate-intensity exercise training in patients with T2DM and to explore the predictors of post-exercise blood glucose (PEBG) and exercise-induced glucose response (EIGR).
METHODS
A prospective longitudinal study was conducted. Of the 66 participants with T2DM recruited from outpatient clinics of a medical center, 20 were eligible to enroll in a 12-week moderate-intensity exercise training. Participants were randomly assigned to 1 of 3 exercise times (morning, afternoon, or evening). Blood glucose were measured pre- and post-exercise. The EIGR was calculated by subtracting the PEBG from the before-exercise blood glucose (BEBG). Generalized estimating equations were used to examine the trends and predictors of PEBG and EIGR.
RESULTS
The BEBG declined progressively (β = -1.69, P < .001); while the PEBG (β = -0.18, P = .08) remained stable over time during the 12-week exercise training. Higher BEBG predicted higher (β = 0.53, P < .001) PEBG. Higher baseline maximum oxygen uptake (VO2max) contributed to a larger magnitude of EIGR; higher HgbA1c and BEBG predicted higher EIGR (β = 0.27, P = .02; β = 0.45, P < .001); afternoon or evening exercise predicted lower (β = -13.2, P = .04; β = -5.96, P = .005) EIGR than did morning exercise.
CONCLUSIONS
A 12-week moderate-intensity exercise training appears safe for patients with T2DM. Time of day for exercise, baseline VO2max, and baseline metabolic control may influence the impact of exercise for individuals with T2DM. These findings provide considerations for design of optimal exercise training for T2DM patients.
背景
2型糖尿病（T2DM）患者对中等强度运动的血糖反应仍不明确。此外，关于12周中等强度运动训练的血糖反应的决定因素知之甚少。因此，本研究旨在探讨T2DM患者在12周中等强度运动训练后的血糖变化趋势，并探索运动后血糖（PEBG）和运动诱导的血糖反应（EIGR）的预测因素。
方法
进行了一项前瞻性纵向研究。从一家医疗中心的门诊招募了66名T2DM参与者，其中20名符合条件参加为期12周的中等强度运动训练。参与者被随机分配到3个运动时间之一（早上、下午或晚上）。在运动前后测量血糖。EIGR通过运动前血糖（BEBG）减去PEBG来计算。使用广义估计方程来检验PEBG和EIGR的变化趋势及预测因素。
结果
在为期12周的运动训练期间，BEBG逐渐下降（β = -1.69，P <.001）；而PEBG（β = -0.18，P =.08）随时间保持稳定。较高的BEBG预测较高的（β = 0.53，P <.001）PEBG。较高的基线最大摄氧量（VO2max）导致更大幅度的EIGR；较高的糖化血红蛋白（HgbA1c）和BEBG预测较高的EIGR（β = 0.27，P =.02；β = 0.45，P <.001）；下午或晚上运动预测的EIGR低于（β = -13.2，P =.04；β = -5.96，P =.005）早上运动。
结论
为期12周的中等强度运动训练对T2DM患者似乎是安全的。运动时间、基线VO2max和基线代谢控制可能会影响T2DM患者运动的效果。这些发现为T2DM患者最佳运动训练方案的设计提供了参考。
Zotero 插件