Bratell S, Folmerz P, Hansson R, Jonsson O, Lundstam S, Pettersson S, Rippe B, Scherstén T
Department of Urology, Sahlgrenska Sjukhuset, Göteborg, Sweden.
Acta Physiol Scand. 1988 Sep;134(1):35-41. doi: 10.1111/j.1748-1716.1988.tb08456.x.
The effect of pretreatment with various substances protecting against oxygen free radicals on the leakage of proteins across the vessel walls of rabbit kidneys induced by ischaemia has been studied. The leakage of proteins was estimated from the difference between the 120-min distribution space of [131I]albumin and the 5-min distribution space of [125I]albumin, the latter mainly measuring the intravascular volume. Neither SOD (superoxide dismutase), catalase, allopurinol or two different Ca2+ channel blockers (nifedipine, felodipine) could alone reduce the leakage induced by ischaemia. A combined pretreatment with SOD, catalase and nifedipine reduced the leakage in the cortex, and pretreatment with mannitol alone reduced the leakage in the cortex and outer stripe of the medulla. The results indicate that oxygen free radicals are involved in the leakage of proteins across the vessel walls induced by ischaemia, but that other mechanisms are involved as well.
