催产素与口腔米索前列醇用于胎膜早破足月引产的比较。
Oxytocin Compared to Buccal Misoprostol for Induction of Labor after Term Prelabor Rupture of Membranes.
机构信息
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.
出版信息
Am J Perinatol. 2021 Feb;38(3):224-230. doi: 10.1055/s-0039-1696642. Epub 2019 Sep 6.
OBJECTIVE
This study was aimed to determine if admission-to-delivery times vary between term nulliparous women with prelabor rupture of membranes (PROM) who initially receive oxytocin compared with buccal misoprostol for labor induction.
STUDY DESIGN
This is a retrospective cohort of 130 term, nulliparous women with PROM and cervical dilation of ≤2 cm who underwent induction of labor with intravenous oxytocin or buccal misoprostol. The primary outcome was time from admission to delivery. Linear regressions with log transformation were used to estimate the effect of induction agent on time to delivery.
RESULTS
Women receiving oxytocin had faster admission-to-delivery times than women receiving misoprostol (16.9 vs. 19.9 hours, = 0.013). There were no significant differences in secondary outcomes between the groups. In the adjusted model, women who received misoprostol had a 22% longer time from admission to delivery (95% CI 5.0-42.0%) compared with women receiving oxytocin.
CONCLUSION
In term nulliparous patients with PROM, intravenous oxytocin is associated with faster admission-to-delivery times than buccal misoprostol.
目的
本研究旨在确定对于初产妇胎膜早破（PROM）且宫颈口扩张程度≤2cm 的产妇，与使用阴道米索前列醇相比，催产素诱导分娩是否会导致不同的入院至分娩时间。
研究设计
本研究为回顾性队列研究，纳入了 130 例足月、初产妇 PROM 且宫颈口扩张程度≤2cm 的产妇，采用静脉滴注催产素或阴道放置米索前列醇进行引产。主要结局是入院至分娩的时间。采用对数变换的线性回归来估计诱导药物对分娩时间的影响。
结果
与米索前列醇相比，接受催产素的产妇入院至分娩的时间更快（16.9 小时比 19.9 小时，=0.013）。两组间次要结局无显著差异。在调整后的模型中，与接受催产素的产妇相比，接受米索前列醇的产妇入院至分娩的时间延长了 22%（95%CI：5.0-42.0%）。
结论
在足月、初产妇 PROM 患者中，与阴道米索前列醇相比，静脉滴注催产素与更快的入院至分娩时间相关。
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