Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Anticancer Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.
Cells. 2019 Sep 5;8(9):1037. doi: 10.3390/cells8091037.
Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The expression of RhoGDIs has changed in many human cancers and become associated with the malignant phenotype, including migration, invasion, metastasis, and resistance to anticancer agents. Here, we review how RhoGDIs control the function of Rho GTPases by regulating their spatiotemporal activity and describe the regulatory mechanisms of the dissociation of Rho GTPases from RhoGDIs. We also discuss the role of RhoGDIs in cancer progression and their potential uses for therapeutic intervention.
Rho GDP 解离抑制剂（RhoGDIs）通过调节 Rho GTPase 家族的功能，在细胞迁移、黏附和增殖等各种细胞过程中发挥重要作用。Rho GTPases 与 RhoGDIs 的解离对于它们的时空激活是必要的，并且受到几种机制的动态调节，例如磷酸化、SUMO 化和蛋白质相互作用。RhoGDIs 的表达在许多人类癌症中发生改变，并与恶性表型相关，包括迁移、侵袭、转移和对抗癌药物的耐药性。在这里，我们综述了 RhoGDIs 如何通过调节 Rho GTPases 的时空活性来控制其功能，并描述了 Rho GTPases 与 RhoGDIs 解离的调节机制。我们还讨论了 RhoGDIs 在癌症进展中的作用及其在治疗干预中的潜在用途。
