Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
Food Chem Toxicol. 2019 Nov;133:110799. doi: 10.1016/j.fct.2019.110799. Epub 2019 Sep 5.
Aluminum (Al) is toxic for humans and animals. Here, we have tested the potential for Egg White Hydrolysate (EWH) to protect against cardiovascular changes in rats exposed to both high and low dietary levels of Al. Indeed, EWH has been previously shown to improve cardio metabolic dysfunctions induced by chronic exposure to heavy metals. Male Wistar rats received orally: Group 1) Low aluminum level (AlCl at a dose of 8.3 mg/kg b.w. during 60 days) with or without EWH treatment (1 g/kg/day); Group 2) High aluminum level (AlCl at a dose of 100 mg/kg b.w. during 42 days) with or without EWH treatment. After Al treatment, rats co-treated with EWH did not show vascular dysfunction or increased blood pressure as was observed in non EWH-cotreated animals. Indeed, co-treatment with EWH prevented the following effects observed in both aorta and mesenteric arteries: the increased vascular responses to phenylephrine (Phe), the decreased ACh-induced relaxation, the reduction on endothelial modulation of vasoconstrictor responses and the nitric oxide bioavailability, as well as the increased reactive oxygen species production from NAD(P)H oxidase. Altogether, our results suggest that EWH could be used as a protective agent against the harmful vascular effects after long term exposure to Al.
铝（Al）对人类和动物有毒。在这里，我们测试了蛋清水解物（EWH）在保护大鼠免受高、低膳食铝暴露引起的心血管变化方面的潜力。事实上，EWH 此前已被证明可改善由长期接触重金属引起的心脏代谢功能障碍。雄性 Wistar 大鼠经口给予：第 1 组）低铝水平（AlCl 剂量为 8.3mg/kg b.w.，持续 60 天），并用或不用 EWH 治疗（1g/kg/day）；第 2 组）高铝水平（AlCl 剂量为 100mg/kg b.w.，持续 42 天），并用或不用 EWH 治疗。在用 Al 处理后，与 EWH 共同治疗的大鼠没有表现出血管功能障碍或血压升高，如未用 EWH 共同治疗的动物所观察到的那样。事实上，EWH 的共同治疗预防了在主动脉和肠系膜动脉中观察到的以下影响：对苯肾上腺素（Phe）的血管反应增加、ACh 诱导的松弛减少、内皮对血管收缩反应的调节和一氧化氮生物利用度的降低，以及 NAD（P）H 氧化酶产生的活性氧增加。总之，我们的结果表明，EWH 可用作长期暴露于 Al 后防止有害血管影响的保护剂。
