睡眠-觉醒周期与海马区 kainic 酸诱导的癫痫病灶区域脑血流之间的关系。
Relationship between sleep-wakefulness cycle and regional cerebral blood flow in kainic acid-induced epileptic focus in hippocampus.
作者信息
Tanaka T, Kunimoto M, Tanaka S, Kondo S, Yonemasu Y
机构信息
Department of Neurosurgery, Asahikawa Medical College.
出版信息
Jpn J Psychiatry Neurol. 1988 Sep;42(3):630-1. doi: 10.1111/j.1440-1819.1988.tb01388.x.
Concurrent monitorings of polygraph and continuous measurements of rCBF of the epileptic focus were made in the nonanesthetized chronic cats. The influences of the sleep-wakefulness cycle on IIDs and rCBF of the epileptic focus of the hippocampus were analyzed. 1) IIDs increased remarkably during LSW and DSW but not as much as during DSW-P. 2) The rCBF decreased gradually during LSW and DSW. But the rCBF during DSW-P increased slightly as compared to that of DSW. 3) The frequencies of IIDs increased in association with hypoperfusion of the epileptic focus. 4) The spiking rate of the hippocampal focus decreased with the appearance of PGO during the deep slow wave sleep stages.
在未麻醉的慢性猫中，同步监测了多导睡眠图，并对癫痫灶的局部脑血流（rCBF）进行了连续测量。分析了睡眠-觉醒周期对海马癫痫灶的发作间期放电（IID）和rCBF的影响。1）在浅慢波睡眠（LSW）和深慢波睡眠（DSW）期间，IID显著增加，但不如深慢波睡眠-阵发性（DSW-P）期间增加得多。2）在LSW和DSW期间，rCBF逐渐降低。但与DSW相比，DSW-P期间的rCBF略有增加。3）IID的频率随着癫痫灶灌注不足而增加。4）在深度慢波睡眠阶段，随着桥脑-膝状体-枕叶波（PGO）的出现，海马灶的放电率降低。
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