Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Trends Neurosci. 2019 Nov;42(11):793-806. doi: 10.1016/j.tins.2019.08.001. Epub 2019 Sep 4.
Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is implicated in various psychiatric and neurological disorders with developmental etiologies. Its consequences on the offspring's mental health are heterogeneous and influenced by a number of factors shaping the specificity and/or severity of pathological outcomes. There is also a substantial degree of resilience to MIA, which determines the extent to which offspring are protected from developing neurodevelopmental sequelae. This review provides a synopsis of the plausible sources that account for the heterogeneous outcomes of MIA and discusses key factors that are critical for establishing neurodevelopmental resilience and susceptibility to this early-life adversity.
母体免疫激活（MIA），无论是由感染性还是非感染性刺激引起的，都与具有发育病因的各种精神和神经疾病有关。其对子代心理健康的影响是异质的，并受到许多因素的影响，这些因素决定了病理性结果的特异性和/或严重程度。MIA 也有很大程度的恢复能力，这决定了后代在多大程度上免受神经发育后遗症的影响。这篇综述概述了导致 MIA 异质结果的可能原因，并讨论了对于确定神经发育恢复力和对这种早期生活逆境的易感性至关重要的关键因素。
