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[精索静脉曲张少精子症患者的治疗]

[Treatment of oligospermic patients with varicocele].

作者信息

Shinoda M, Naide Y, Tazaki H

机构信息

Department of Urology, School of Medicine, Fujita Gakuen Health University.

出版信息

Hinyokika Kiyo. 1988 Nov;34(11):1989-94.

PMID:3149452
Abstract

The management of oligospermic patients with varicocele was reviewed. Varicocelectomy was performed in 46 oligospermic patients with varicocele (group 1) and kallikrein treatment was followed for those who failed to improve the semen quality after varicocelectomy (group 2). Twenty oligospermic patients with varicocele were given kallikrein for over 6 months as an initial treatment (group 3). A significant increase in total motile sperm count was noted in 34.8% of the patients in group 1, 22.7% in group 2, and 30.0% in group 3 respectively. Conception rate which was calculated after excluding couples, in which the partner received either artificial insemination by husband or any gynecological treatment, was 20.8% in group 1, 15.4% in group 2, 25.0% in group 3 respectively. No significant changes in hormonal data was observed after either treatment, but semen quality was not improved in patients who showed high serum level of luteinizing hormone (LH) or follicle stimulating hormone (FSH). Kallikrein is useful for oligospermic patients with varicocele as an initial treatment and for those in whom semen quality was not improved after varicocelectomy. Varicocelectomy and/or kallikrein treatment can be recommended mainly for those who show normal serum level of LH and FSH.

摘要

对少精子症精索静脉曲张患者的治疗进行了回顾。46例少精子症精索静脉曲张患者接受了精索静脉结扎术(第1组),精索静脉结扎术后精液质量未改善的患者接受了激肽释放酶治疗(第2组)。20例少精子症精索静脉曲张患者作为初始治疗接受激肽释放酶治疗超过6个月(第3组)。第1组、第2组和第3组患者中,分别有34.8%、22.7%和30.0%的患者总活动精子数显著增加。排除配偶接受丈夫人工授精或任何妇科治疗的夫妇后计算的受孕率,第1组为20.8%,第2组为15.4%,第3组为25.0%。两种治疗后激素数据均未观察到显著变化,但血清促黄体生成素(LH)或促卵泡生成素(FSH)水平高的患者精液质量未改善。激肽释放酶作为初始治疗对少精子症精索静脉曲张患者以及精索静脉结扎术后精液质量未改善的患者有用。精索静脉结扎术和/或激肽释放酶治疗主要可推荐给血清LH和FSH水平正常的患者。

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