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骨关节炎感染:老年患者的专项治疗方案?

Osteoarticular infections: a specific program for older patients?

机构信息

Infectiology, Balgrist University Hospital, Forchstrasse 340, 8008, Zurich, Switzerland.

Infection Control, Balgrist University Hospital, Zurich, Switzerland.

出版信息

Aging Clin Exp Res. 2021 Mar;33(3):703-710. doi: 10.1007/s40520-019-01329-w. Epub 2019 Sep 7.

DOI:10.1007/s40520-019-01329-w
PMID:31494913
Abstract

BACKGROUND

With the increasing number of elderly patients, arthroplasties, fractures and diabetic foot infections, the worldwide number of osteoarticular infections (OAI) among the elderly is concomitantly expected to rise.

AIMS

We explore existing scientific knowledge about OAI in the frail elderly population.

METHODS

We performed a literature search linking OAIs to geriatric patients and comparing elderly patients (> 65 years) with average adults (range 18-65 years).

RESULTS

In this literature, financial aspects, comparison of diverse therapies on quality of life, reimbursement policies, or specific guidelines or nursing recommendations are missing. Age itself was not an independent factor related to particular pathogens, prevention of OAI, nursing care, and outcomes of OAI. However, geriatric patients were significantly more exposed to adverse events of therapy. They had more co-morbidities and more conservative surgery for OAI.

CONCLUSION

Available literature regarding OAI management among elderly patients is sparse. In recent evaluations, age itself does not seem an independent factor related to particular epidemiology, pathogens, prevention, nursing care, rehabilitation and therapeutic outcomes of OAI. Future clinical research will concern more conservative surgical indications, but certainly reduce inappropriate antibiotic use.

摘要

背景

随着老年患者、关节置换术、骨折和糖尿病足感染数量的增加,预计全球老年人群中的骨关节炎感染(OAI)也会相应增加。

目的

我们探索了脆弱老年人群中 OAI 的现有科学知识。

方法

我们进行了一项文献检索,将 OAI 与老年患者联系起来,并将老年患者(>65 岁)与普通成年人(18-65 岁)进行比较。

结果

在这篇文献中,缺乏财务方面的内容,如不同治疗方法对生活质量的比较、报销政策或特定的指南或护理建议。年龄本身并不是与特定病原体、OAI 预防、护理以及 OAI 结果相关的独立因素。然而,老年患者明显更容易受到治疗的不良事件的影响。他们有更多的合并症,并且对 OAI 的手术治疗更为保守。

结论

关于老年患者 OAI 管理的现有文献很少。在最近的评估中,年龄本身似乎不是与特定的流行病学、病原体、预防、护理、康复和 OAI 治疗结果相关的独立因素。未来的临床研究将关注更保守的手术指征,但肯定会减少不适当的抗生素使用。

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Diabetes Obes Metab. 2019 Jun;21(6):1483-1486. doi: 10.1111/dom.13651. Epub 2019 Mar 12.
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Oral versus Intravenous Antibiotics for Bone and Joint Infection.口服与静脉用抗生素治疗骨与关节感染。
N Engl J Med. 2019 Jan 31;380(5):425-436. doi: 10.1056/NEJMoa1710926.
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Should antibiotic prophylaxis before orthopedic implant surgery depend on the duration of pre-surgical hospital stay?骨科植入物手术前是否应该使用抗生素预防?这取决于术前住院时间长短吗?
血运重建时机及肠外抗生素治疗与缺血性糖尿病足感染治疗失败的相关性
Antibiotics (Basel). 2023 Mar 31;12(4):685. doi: 10.3390/antibiotics12040685.
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Nutritional Interventions May Improve Outcomes of Patients Operated on for Diabetic Foot Infections: A Single-Center Case-Control Study.营养干预可能改善糖尿病足感染患者手术治疗的结局:一项单中心病例对照研究。
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Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections.骨关节炎感染中抗生素的模型指导精准给药
Infect Drug Resist. 2022 Jan 11;15:99-110. doi: 10.2147/IDR.S332366. eCollection 2022.
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Is malnutrition associated with orthopaedic infections? A single-centre pilot evaluation.营养不良与骨科感染有关吗?单中心初步评估。
J Hosp Infect. 2019 Feb;101(2):229-230. doi: 10.1016/j.jhin.2018.11.006. Epub 2018 Nov 13.
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Remission in diabetic foot infections: Duration of antibiotic therapy and other possible associated factors.糖尿病足感染的缓解:抗生素治疗的持续时间和其他可能的相关因素。
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