2011年至2015年中国腹腔感染中分离出的腹腔感染病原体的抗菌药敏变化及[此处原文缺失部分内容]。
Antimicrobial susceptibility changes of and intra-abdominal infection isolate-derived pathogens from Chinese intra-abdominal infections from 2011 to 2015.
作者信息
Zhang Hui, Tong Dawei, Johnson Aaron, Zhang Ge, Xu Zhipeng, Yang Yang, Zhang Jingjia, Li Dongxue, Duan Simeng, Wang Yao, Yang Qiwen, Xu Yingchun
机构信息
Department of Microbiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, People's Republic of China.
Department of Microbiology, International Health Management Associates, Schaumburg, IL 60173-3817, USA.
出版信息
Infect Drug Resist. 2019 Aug 9;12:2477-2486. doi: 10.2147/IDR.S211952. eCollection 2019.
BACKGROUND
To explore the susceptibility trends of antimicrobials and resistance increase to antibiotics of isolated from patients in China with intra-abdominal infections (IAI) from 2011 to 2015.
METHODS
MIC and MIC values of 12 commonly used antibiotics from and isolated from IAI samples were determined.
RESULTS
A total of 8,477 Gram-negative bacterial pathogens were collected from 21 medical centers in China. The majority of IAI isolate-derived pathogens were (3,854, 45.5%) and (1,670, 19.7%) of which 1,990 (23.5%) were consecutively collected from community acquired (CA) and 6,186 (73.0%) from hospital acquired (HA) IAIs. The drugs with the highest efficacy against and isolates derived from IAI samples were imipenem, ertapenem, amikacin and piperacillin-tazobactam. MIC values for piperacillin-tazobactam were 64 µg/mL in 2015 with fluctuations from 16-64 µg/mL through the years for , but were stable at ≥64 µg/mL from 2011 to 2015 for isolates. Susceptibilities to ertapenem, imipenem and amikacin were high for isolates throughout the study, but isolated from abscesses, colon and peritoneal fluid collected from medical and surgical ICUs showed an increasing trend of carbapenem resistance in 2015.
CONCLUSION
In 2015 there was a trend of enhanced carbapenem resistance, particularly for isolated from IAI samples obtained from patients in ICUs.
背景
探讨2011年至2015年中国腹腔内感染（IAI）患者分离菌株对抗菌药物的敏感性趋势及抗生素耐药性增加情况。
方法
测定从IAI样本中分离的菌株对12种常用抗生素的MIC和MIC值。
结果
从中国21个医疗中心共收集到8477株革兰阴性菌病原体。IAI分离菌株来源的病原体大多数是大肠埃希菌（3854株，45.5%）和肺炎克雷伯菌（1670株，19.7%），其中1990株（23.5%）是从社区获得性（CA）IAI连续收集的，6186株（73.0%）是从医院获得性（HA）IAI收集的。对IAI样本分离的大肠埃希菌和肺炎克雷伯菌菌株疗效最高的药物是亚胺培南、厄他培南、阿米卡星和哌拉西林-他唑巴坦。2015年哌拉西林-他唑巴坦对大肠埃希菌的MIC值为64μg/mL，多年来在16 - 64μg/mL波动，但2011年至2015年对肺炎克雷伯菌分离株稳定在≥64μg/mL。在整个研究中，厄他培南、亚胺培南和阿米卡星对肺炎克雷伯菌分离株的敏感性较高，但2015年从内科和外科重症监护病房收集的脓肿、结肠和腹腔液中分离的肺炎克雷伯菌显示碳青霉烯类耐药性呈上升趋势。
结论
2015年出现碳青霉烯类耐药性增强趋势，特别是从重症监护病房患者的IAI样本中分离的肺炎克雷伯菌。
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