Nam Dae-Hwan, Park Jinsook, Park Sun-Hyun, Kim Ki-Suk, Baek Eun Bok
Predictive Model Research Center, Korea Institute of Toxicology, Daejeon 34114, Korea.
Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Korean J Physiol Pharmacol. 2019 Sep;23(5):329-334. doi: 10.4196/kjpp.2019.23.5.329. Epub 2019 Aug 26.
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
糖尿病与心血管并发症风险增加相关。二肽基肽酶-4（DPP-IV）抑制剂作为一种抗糖尿病药物在临床上用于降低高血糖水平。然而，DPP-IV抑制剂吉格列汀对缺血/再灌注（I/R）诱导的心肌损伤和高血压的影响尚不清楚。在本研究中，我们评估了吉格列汀在大鼠心肌I/R损伤和自发性高血压模型中的作用及机制。在诱导I/R损伤前4周，将吉格列汀（20和100 mg/kg/d）或赋形剂经胃内给予斯普拉格-道利大鼠。与赋形剂对照组相比，吉格列汀通过改善血流动力学功能和减小梗死面积对I/R损伤发挥预防作用。此外，在食物中添加吉格列汀（0.03%和0.15%）粉末4周可逆转自发性高血压大鼠的心肌肥厚并改善舒张功能。我们在此报告吉格列汀对I/R损伤和高血压的新作用。
