Tomizawa S, Suzuki S, Oguri M, Kuroume T
Nephron. 1979;24(4):179-82. doi: 10.1159/000181712.
Plasma obtained from patients with MCNS in active stage suppressed the 3H-TdR incorporation of autologous or homologous lymphocytes stimulated with PHA-P and E rosette formation, while plasma from patients in remission did not. The depressed mitogenic response of lymphocytes from patients in the active stage significantly improved when the patient's plasma was substituted for the plasma from inactive MCNS or healthy persons and fetal calf serum. In the preliminary experiment, it was seen that the inhibitory factors were heat stable at 56 degrees C, unadsorbable to charcoal powder and retained in both the permeable and impermeable fractions of collodion bag.
活动期微小病变肾病综合征（MCNS）患者的血浆抑制了经植物血凝素-P（PHA-P）刺激的自体或同源淋巴细胞的3H-胸腺嘧啶核苷掺入及E玫瑰花结形成，而缓解期患者的血浆则无此作用。当用患者的血浆替代非活动期MCNS患者或健康人的血浆及胎牛血清时，活动期患者淋巴细胞的促有丝分裂反应明显改善。在初步实验中，发现抑制因子在56℃时热稳定，不能被活性炭吸附，并保留在火棉胶袋的可渗透和不可渗透部分。
