Qiu Xiumin, Wang Xin, Hou Shengzhen, Zhang Jin, Zhou Jing, Tan Yebang
School of Chemistry and Chemical Engineering, Key Laboratory of Special Functional Aggregated Materials, Key Laboratory of Colloid and Interface Chemistry, Ministry Education, Shandong University, Jinan 250100, China.
School of Light Industry and Engineering, Qilu University of Technology, Jinan 250353, China.
Polymers (Basel). 2019 Sep 9;11(9):1470. doi: 10.3390/polym11091470.
There is an urgent need for new strategies that allow the simultaneous detection and control of drug delivery. By making use of supramolecular host-guest interactions, a kind of pseudopolyrotaxanes, as a visualizable nanoscale drug carrier has been constructed by self-assembly of cucurbit[7]uril (CB[7]) with methoxy poly(ethylene glycol)--quaternized poly(4-vinyl pyridine) (mPEG--QP4VP) using 4-(chloromethyl)benzonitrile. Simple addition of CB[7] into an aqueous solution of mPEG--QP4VP resulted in noncovalent attachment of CB[7] to 4-cyanobenzyl-containing polymers, transforming the nonemissive mPEG--QP4VP micelles into highly fluorescent micelles. These pseudopolyrotaxanes micelles exhibited remarkable supramolecular assembly-induced emission enhancement and excellent biocompatibility, showing great potential for bioimaging applications. In addition, the efficient cellular uptake of the developed pseudopolyrotaxanes micelles loaded with the anticancer drug doxorubicin was a promising platform for simultaneous cell imaging and drug delivery, thereby widening their application in cancer theranostics.
迫切需要能够同时实现药物递送检测与控制的新策略。利用超分子主客体相互作用，通过葫芦[7]脲（CB[7]）与甲氧基聚（乙二醇）-季铵化聚（4-乙烯基吡啶）（mPEG-QP4VP）以4-（氯甲基）苄腈为原料进行自组装，构建了一种可视的纳米级药物载体——一种准聚轮烷。将CB[7]简单添加到mPEG-QP4VP的水溶液中，会使CB[7]非共价连接到含4-氰基苄基的聚合物上，将不发光的mPEG-QP4VP胶束转变为高荧光胶束。这些准聚轮烷胶束表现出显著的超分子组装诱导发光增强和优异的生物相容性，在生物成像应用中显示出巨大潜力。此外，负载抗癌药物阿霉素的所开发的准聚轮烷胶束能够高效地被细胞摄取，是用于同时进行细胞成像和药物递送的有前景的平台，从而拓宽了它们在癌症诊疗中的应用。
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