Department of Orthopedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 697-24 Hwajung-dong, Deokyang-gu, Goyang-si, Gyeonggi-do 10475, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Myongji Hospital, Hanyang University College of Medicine, 697-24 Hwajung-dong, Deokyang-gu, Goyang-si, Gyeonggi-do 10475, Republic of Korea.
Foot Ankle Surg. 2020 Aug;26(6):657-661. doi: 10.1016/j.fas.2019.08.005. Epub 2019 Sep 4.
BACKGROUND: This study aimed to compare the efficacy and safety of polydeoxyribonucleotide (PDRN) injection and corticosteroid injection for plantar fasciitis. METHODS: This study included 44 patients with plantar fasciitis, randomly allocated to the PDRN and corticosteroid groups. Evaluation using the visual analogue scale (VAS) pain score and Manchester-Oxford foot questionnaire (MOXFQ) was conducted at baseline, 1, 2, 6weeks and 6months. The thickness and echogenicity of the plantar fascia in ultrasonography and complications were recorded. RESULTS: Corticosteroid injection elicited more pain relief than did PDRN injection at 2 (p=0.010) and 6weeks (p=0.016); however, it showed no superiority at 6months (p=0.523). MOXFQ showed similar outcomes. The thickness and echogenicity did not differ between groups and no complications were reported in either group. CONCLUSIONS: We demonstrated that PDRN injection could be an effective and safe option for plantar fasciitis and was comparable to corticosteroid injection after 6months follow up. LEVEL OF EVIDENCE: II, comparative study.
背景：本研究旨在比较聚脱氧核糖核苷酸（PDRN）注射和皮质类固醇注射治疗足底筋膜炎的疗效和安全性。
方法：本研究纳入了 44 例足底筋膜炎患者，随机分为 PDRN 组和皮质类固醇组。在基线、1、2、6 周和 6 个月时使用视觉模拟评分（VAS）疼痛评分和曼彻斯特-牛津足部问卷（MOXFQ）进行评估。记录超声检查中足底筋膜的厚度和回声以及并发症。
结果：皮质类固醇注射在 2 周（p=0.010）和 6 周（p=0.016）时比 PDRN 注射更能缓解疼痛，但在 6 个月时没有优势（p=0.523）。MOXFQ 也得出了类似的结果。两组之间的厚度和回声没有差异，两组均未报告并发症。
结论：我们证明 PDRN 注射是治疗足底筋膜炎的一种有效且安全的选择，与皮质类固醇注射相比，在 6 个月的随访后具有可比性。
证据水平：II，比较研究。
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