Saxén L, Sariola H
Department of Pathology, University of Helsinki, Finland.
Pediatr Nephrol. 1987 Jul;1(3):385-92. doi: 10.1007/BF00849241.
The mammalian permanent kidney consists of three cell lineages of different origin: the epithelial cells of the ureter bud, the mesenchymal cells of the nephric blastema and the endothelial cells of the capillaries. Organogenesis is governed by a cascade of morphogenetic interactions between these cell populations, a reciprocal epithelial-mesenchymal interaction between the branching ureter and the metanephric mesenchyme, homotypic interactions between cells of the tubular anlagen, stimulation of angiogenesis by the differentiating blastema and a mesenchymal--endothelial interaction guiding the migration of the capillary endothelial cells. While the biology of these interactive events is well known, as described in this overview, the molecular mechanisms are less well mapped out.
输尿管芽的上皮细胞、肾胚基的间充质细胞和毛细血管的内皮细胞。器官发生受这些细胞群体之间一系列形态发生相互作用的支配，即分支输尿管与后肾间充质之间的上皮-间充质相互作用、管状原基细胞之间的同型相互作用、分化的胚基对血管生成的刺激以及引导毛细血管内皮细胞迁移的间充质-内皮相互作用。如本综述所述，虽然这些相互作用事件的生物学原理已为人熟知，但其分子机制尚不十分明确。
