仓鼠细胞上的白喉毒素结合糖蛋白：白喉毒素受体的候选物。
Diphtheria toxin-binding glycoproteins on hamster cells: candidates for diphtheria toxin receptors.
作者信息
Proia R L, Eidels L, Hart D A
出版信息
Infect Immun. 1979 Sep;25(3):786-91. doi: 10.1128/iai.25.3.786-791.1979.
Abstract
Diphtheria toxin-binding glycoproteins of high molecular weight (greater than 100,000) were identified on the surface of lymph node and thymus cells from hamsters, a diphtheria toxin-sensitive species. These diphtheria toxin-binding glycoproteins also interacted with CRM197 protein, which possesses toxin-blocking activity, but not with diphtheria toxoid, fragment A of diphtheria toxin, or cholera toxin, all of which lack toxin-blocking activity. These observations are consistent with the hypothesis that the detected diphtheria toxin-binding glycoproteins are involved in intoxication of cells by this toxin and possibly serve as the plasma membrane receptors for diphtheria toxin.
摘要
在对白喉毒素敏感的仓鼠的淋巴结和胸腺细胞表面，鉴定出了高分子量（大于100,000）的白喉毒素结合糖蛋白。这些白喉毒素结合糖蛋白还与具有毒素阻断活性的CRM197蛋白相互作用，但不与白喉类毒素、白喉毒素A片段或霍乱毒素相互作用，后三者均缺乏毒素阻断活性。这些观察结果与以下假设一致，即检测到的白喉毒素结合糖蛋白参与了该毒素对细胞的毒害作用，并且可能作为白喉毒素的质膜受体。
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2
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Biochem Biophys Res Commun. 1967 Sep 7;28(5):815-20. doi: 10.1016/0006-291x(67)90391-9.
3
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Annu Rev Biochem. 1974;43(0):169-214. doi: 10.1146/annurev.bi.43.070174.001125.
4
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Biochem Biophys Res Commun. 1971 Jul 16;44(2):390-5. doi: 10.1016/0006-291x(71)90612-7.
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