Department of Bioinformatics, Computer-Aided Drug Design, and Molecular Modeling Lab, Science Block, Alagappa University, Karaikudi, Tamil Nadu, 630004, India.
Center of Interdisciplinary Sciences-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Curr Drug Targets. 2020;21(2):132-147. doi: 10.2174/1389450119666190920152249.
Ion channels are integral proteins expressed in almost all living cells and are involved in muscle contraction and nutrient transport. They play a critical role in the normal functioning of the excitable tissues of the nervous system and regulate the action potential and contraction events. Dysfunction of genes encodes ion channel proteins, which disrupt the channel function and lead to a number of diseases, among which is type 1 diabetes mellitus (T1DM). Therefore, understanding the complex mechanism of ion channel receptors is necessary to facilitate the diagnosis and management of treatment. In this review, we summarize the mechanism of important ion channels and their potential role in the regulation of insulin secretion along with the limitations of ion channels as therapeutic targets. Furthermore, we discuss the recent investigations of the mechanism regulating the ion channels in pancreatic beta cells, which suggest that ion channels are active participants in the regulation of insulin secretion.
离子通道是几乎所有活细胞中表达的整合蛋白，参与肌肉收缩和营养物质运输。它们在神经系统兴奋组织的正常功能中起着关键作用，并调节动作电位和收缩事件。离子通道蛋白编码基因的功能障碍会破坏通道功能，导致多种疾病，其中包括 1 型糖尿病（T1DM）。因此，了解离子通道受体的复杂机制对于促进诊断和治疗管理是必要的。在这篇综述中，我们总结了重要离子通道的机制及其在调节胰岛素分泌中的潜在作用，以及离子通道作为治疗靶点的局限性。此外，我们还讨论了最近对调节胰腺β细胞中离子通道机制的研究，表明离子通道是胰岛素分泌调节的积极参与者。
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