早产围产期缺氧缺血不影响成年大鼠的体感诱发电位。
Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats.
作者信息
Barkhuizen Melinda, Vles Johan S H, van Mechelen Ralph, Vermeer Marijne, Kramer Boris W, Chedraui Peter, Bergs Paul, van Kranen-Mastenbroek Vivianne H J M, Gavilanes Antonio W D
机构信息
Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands.
Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands.
出版信息
Diagnostics (Basel). 2019 Sep 18;9(3):123. doi: 10.3390/diagnostics9030123.
Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.
体感诱发电位（SSEPs）是评估体感通路功能完整性以及预测围产期损伤（如围产期缺氧缺血性损伤，HI）中感觉运动预后的重要工具。在本研究中，我们将围产期HI成年雄性大鼠与健康成年雄性大鼠进行比较，研究了SSEPs与感觉功能的转化潜力。在围产期HI后10至11个月测量体感反应和诱发电位。获得了清晰的诱发电位，但两组在先前感觉反应的诱发电位幅度或潜伏期方面没有差异。两组的双侧触觉刺激测试也均正常。这种缺乏效应可能归因于测试时大鼠的年龄较大以及功能恢复。
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