Searl Jeff, Knollhoff Stephanie
University of Kansas Medical Center, Kansas City, KS, United States.
University of Kansas Medical Center, Kansas City, KS, United States.
J Commun Disord. 2019 Nov-Dec;82:105937. doi: 10.1016/j.jcomdis.2019.105937. Epub 2019 Sep 10.
The aim of this study was to compare the percentage of the maximum isometric lingual strength range at which lingual-alveolar consonants are produced (%P) by people with amyotrophic lateral sclerosis (PALS) compared to people without the disease measured at study entry, and then 3 and 6 months later.
Prospective cohort comparison study over time.
Ten people with ALS and nine without produced the consonants /t, d, s, z, l, n/ in real words within sentences as the articulatory contact pressure (ACP) between the tongue tip and palate was sensed by a miniature transducer. Maximum isometric tongue pressing values also were obtained to allow calculation of %P. Data were analyzed to compare PALS with bulbar symptoms, PALS with spinal-only symptoms, and people without ALS.
%P did not differ between any of the three participant groups at any of the three measurement times. Maximum isometric pressure did decrease significantly in both ALS groups when comparing baseline to 3- and 6-months later. Maximum pressures remained stable for the non-ALS group at the three measurement times.
The results suggest that speech motor activity of the tongue in people with ALS may be scaled relative to their overall tongue strength, such that the %P does not change as the tongue gets progressively weaker.
本研究旨在比较肌萎缩侧索硬化症患者（PALS）与未患该疾病者在研究开始时、3个月后和6个月后，发出舌齿龈辅音时最大等长舌力范围的百分比（%P）。
随时间进行的前瞻性队列比较研究。
10名肌萎缩侧索硬化症患者和9名非患者在句子中以真实单词发出辅音/t、d、s、z、l、n/，同时通过微型传感器感知舌尖与上颚之间的发音接触压力（ACP）。还获取了最大等长舌压值以计算%P。对数据进行分析，以比较有延髓症状的PALS、仅有脊髓症状的PALS和无肌萎缩侧索硬化症的人。
在三个测量时间点中的任何一个，三个参与者组中的任何一组之间的%P均无差异。与基线相比，3个月和6个月后，两个肌萎缩侧索硬化症组的最大等长压力均显著降低。非肌萎缩侧索硬化症组在三个测量时间点的最大压力保持稳定。
结果表明，肌萎缩侧索硬化症患者的舌部言语运动活动可能与其整体舌力相关，因此随着舌头逐渐变弱，%P不会改变。
